{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:40:54Z","timestamp":1777945254021,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cardiac rehabilitation (CR) improves exercise capacity, but frequent cardiopulmonary exercise testing (CPET) is impractical. The AESCULON mini enables non\u2010invasive hemodynamic monitoring, though its role in CR remains unclear. Eleven patients (6 myocardial infarction, 3 angina pectoris, 2 dilated cardiomyopathy) undergoing outpatient CR at the University of Tokyo Hospital were studied. Hemodynamics were measured using the AESCULON mini before and after 20\u2009min of aerobic exercise at the anaerobic threshold. CPET and brain natriuretic peptide (BNP) were assessed within 2\u2009weeks. Stroke volume, cardiac output, and cardiac index tended to increase, and thoracic fluid content (TFC) decreased post\u2010exercise. TFC before (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.767,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) and after (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.711,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) correlated with BNP. Changes in stroke volume and cardiac output correlated with peak VO\n                    <jats:sub>2<\/jats:sub>\n                    , percent predicted peak VO\n                    <jats:sub>2<\/jats:sub>\n                    , and \u0394VO\n                    <jats:sub>2<\/jats:sub>\n                    \/\u0394WR. Patients with increased cardiac output during exercise had higher peak VO\n                    <jats:sub>2<\/jats:sub>\n                    and \u0394VO\n                    <jats:sub>2<\/jats:sub>\n                    \/\u0394WR. Non\u2010invasive hemodynamic data from the AESCULON mini correlated with BNP and exercise capacity, suggesting its usefulness for detecting heart failure progression and estimating exercise capacity in CR.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70768","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:24:50Z","timestamp":1772969090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ensuring safety of exercise training through non\u2010invasive measurement of cardiac function: A pilot study in adults"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-3997","authenticated-orcid":false,"given":"Takayuki","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Computational Diagnostic Radiology and Preventive Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2810-8040","authenticated-orcid":false,"given":"Eisuke","family":"Amiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine JR Tokyo General Hospital  Shibuya\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute  Fuchu Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Rehabilitation The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Taya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Rehabilitation The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Komuro","sequence":"additional","affiliation":[{"name":"Department of Frontier Cardiovascular Science The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"},{"name":"International University of Health and Welfare  Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft026"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.001061"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02344724"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001289"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009629"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.060"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20160171"},{"issue":"12","key":"e_1_2_11_11_1","first-page":"1208","article-title":"Development and evaluation of an impedance cardiac output system","volume":"37","author":"Kubicek W. 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