{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:53:39Z","timestamp":1780044819906,"version":"3.53.1"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heart rate variability (HRV) is a sensitive marker of autonomic regulation. This study examined adolescents in the long\u2010term postoperative period after early surgical correction of aortic coarctation (CoA) compared with age\u2010matched healthy peers. Seventy adolescents (35 CoA, 35 controls; 12\u201317\u2009years) underwent 5\u2010min resting ECG and respiratory monitoring. HRV was analyzed using time domain, frequency domain, and nonlinear methods; respiratory rate was included as a covariate in ANCOVA models. Adolescents with repaired CoA showed lower time domain indices (SDNN, RMSSD, pNN50; all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), reduced total spectral power (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), and higher VLF (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Group differences in SDNN, RMSSD, and the LF\/HF remained significant after adjustment for respiratory rate, indicating that autonomic alterations were not explained by breathing patterns. Nonlinear analysis revealed reduced Poincar\u00e9 plot parameters (SD1, SD2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and higher fractal scaling (DFA Alpha2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in the CoA group, whereas entropy measures and DFA Alpha1 did not differ. These findings demonstrate persistent and selective alterations in autonomic regulation during adolescence despite anatomically successful repair. The coexistence of altered and preserved HRV features suggests domain specific reorganization rather than uniform loss of complexity. Nonlinear HRV indices may improve long term monitoring and help guide individualized rehabilitation.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70769","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:22:16Z","timestamp":1770445336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heart rate variability changes in adolescents following surgical correction of aortic coarctation: Persistent autonomic alterations"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-4280","authenticated-orcid":false,"given":"O. V.","family":"Shevaldova","sequence":"first","affiliation":[{"name":"A.N. Bakulev Center for Cardiovascular Surgery of the Russian Ministry of Health  Moscow Russia"},{"name":"Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies (Anokhin Research Institute of Normal Physiology)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-3408","authenticated-orcid":false,"given":"A. V.","family":"Kovaleva","sequence":"additional","affiliation":[{"name":"Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies (Anokhin Research Institute of Normal Physiology)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-9136","authenticated-orcid":false,"given":"A. Yu.","family":"Zavarina","sequence":"additional","affiliation":[{"name":"A.N. Bakulev Center for Cardiovascular Surgery of the Russian Ministry of Health  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-1576","authenticated-orcid":false,"given":"E. N.","family":"Likhomanova","sequence":"additional","affiliation":[{"name":"Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies (Anokhin Research Institute of Normal Physiology)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-716X","authenticated-orcid":false,"given":"E. N.","family":"Panova","sequence":"additional","affiliation":[{"name":"Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies (Anokhin Research Institute of Normal Physiology)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3784-7260","authenticated-orcid":false,"given":"O. B.","family":"Obryvchenko","sequence":"additional","affiliation":[{"name":"A.N. Bakulev Center for Cardiovascular Surgery of the Russian Ministry of Health  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010025\u201004020\u20102"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2012.6346890"},{"key":"e_1_2_11_4_1","first-page":"87","article-title":"Stress, illness and learning as the conditions of regression","volume":"4","author":"Alexandrov Y. 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