{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:13:12Z","timestamp":1791637992704,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Seasonal differences in temperature and ultraviolet radiation (UVR) exposure may alter NO\u2010mediated vasodilation in the cutaneous microvasculature. We assessed seasonal variation in cutaneous microvascular function in 10 healthy (23\u2009\u00b1\u20092; 6 men, 4 women) adults in the summer\/early\u2010fall and winter\/early\u2010spring. Microvascular (intradermal microdialysis and local skin heating [42\u00b0C]) endothelial function was assessed at two visits separated by ~6\u2009months. Mean daytime (sunrise to sunset) outdoor temperature and 2\u2010h peak UV Index were recorded for the 30\u2009days prior to each experimental visit. Serum vitamin D concentrations [25(OH)D] were measured for each visit. Multivariate regression analysis evaluated the factors (temperature, UV Index, and [25(OH)D]) that best explained variance in microvascular endothelial function. The local heating response (74.37\u2009\u00b1\u200912.21 %CVC\n                    <jats:sub>max<\/jats:sub>\n                    vs. 55.89\u2009\u00b1\u200915.50 %CVC\n                    <jats:sub>max<\/jats:sub>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009) and the NO contribution to that response (61.73%\u2009\u00b1\u20099.67% vs. 38.13%\u2009\u00b1\u200913.26%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004) were lower in winter\/early\u2010spring compared to summer\/early\u2010fall. The best\u2010fit regression model suggested that 30\u2010day average outdoor temperature and 2\u2010h peak UV Index were positively and negatively associated with NO\u2010dependent cutaneous vasodilation, respectively. Healthy adults exhibit lower NO\u2010mediated cutaneous vasodilation in the winter\/early\u2010spring compared with summer\/early\u2010fall, which is partially explained by seasonal differences in outdoor temperature.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70784","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:10:48Z","timestamp":1771499448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cutaneous microvascular function is reduced in winter compared with summer in healthy young adults"],"prefix":"10.14814","volume":"14","author":[{"given":"James F.","family":"Bangle","sequence":"first","affiliation":[{"name":"Department of Kinesiology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa J.","family":"Guadagni","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia R.","family":"Albino","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Grundstein","sequence":"additional","affiliation":[{"name":"Department of Geography University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-2143","authenticated-orcid":false,"given":"S. Tony","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013\u20101252"},{"key":"e_1_2_12_3_1","unstructured":"Bangle J. F.(2025).Seasonal Variations in Endothelial Function and Blood Pressure Control in Young Healthy Adults. 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