{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:14:23Z","timestamp":1791598463340,"version":"4.3.4"},"reference-count":79,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stress\u2010induced hemodynamic reactivity was categorized as predominant alpha (\u03b1)\u2010 and beta (\u03b2)\u2010adrenergic reactivity profiles. Within these profiles, we investigated resting neuroendocrine markers, their associations with hemodynamic reactivity, and odds of an \u03b1\u2010 or \u03b2\u2010adrenergic reactivity profile. We included 375 teachers (20\u201365\u2009years) and recorded one\u2010minute beat\u2010to\u2010beat hemodynamic reactivity during Stroop\u2010Color\u2010Word\u2010Conflict\u2010test. We categorized \u03b1\u2010responders [lowest\u2010quartile \u2206%CO, \u2206%Cwk;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200949], \u03b2\u2010responders [highest\u2010quartile \u2206%CO, \u2206%Cwk;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200969], mixed\u2010\u03b1\/\u03b2\u2010responders [remaining\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009257]. Baseline fasting serum adrenocorticotropic hormone (ACTH), cortisol, urinary norepinephrine\u2010to\u2010creatinine (u\u2010NE\/Cr), and epinephrine\u2010to\u2010creatinine (u\u2010EPI\/Cr) ratios were measured. Predominant \u03b1\u2010responders were older with greater hypertension prevalence than other responders. In \u03b1\u2010responders, u\u2010NE\/Cr inversely, and ACTH and cortisol positively associated with \u2206%CO and \u2206%Cwk (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.044). In \u03b2\u2010responders, u\u2010NE\/Cr positively associated with \u2206%CO, u\u2010EPI\/Cr inversely with \u2206%CO, and positively with \u2206%Cwk (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.045). Odds of an \u03b1\u2010profile were higher with u\u2010NE\/Cr, ACTH, and cortisol in the highest\u2010quartile (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.004). Odds of a \u03b2\u2010profile were higher with u\u2010NE\/Cr in the highest\u2010quartile and ACTH and cortisol in the lowest\u2010quartile (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.006). Predominant \u03b1\u2010responders exhibited higher u\u2010NE\/Cr, ACTH, and cortisol, suggesting vascular risk through peripheral vasoconstriction. Predominant \u03b2\u2010responders showed higher u\u2010NE\/Cr only, suggesting adaptive cardiac performance via catecholaminergic drive. These findings reveal distinct neuroendocrine underpinnings with implications for personalized acute stress cardiovascular phenotyping.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70809","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:01:58Z","timestamp":1773716518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resting neuroendocrine markers in relation to acute mental stress\u2010induced adrenergic reactivity profiles in adults: The\n                    <scp>SABPA<\/scp>\n                    study"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-0953","authenticated-orcid":false,"given":"Dewald","family":"Naud\u00e9","sequence":"first","affiliation":[{"name":"Hypertension in Africa Research Team (HART) North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-7331","authenticated-orcid":false,"given":"Wayne","family":"Smith","sequence":"additional","affiliation":[{"name":"Hypertension in Africa Research Team (HART) North\u2010West University  Potchefstroom South Africa"},{"name":"South African Medical Research Council Unit for Hypertension and Cardiovascular Disease North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-5129","authenticated-orcid":false,"given":"Roland","family":"von K\u00e4nel","sequence":"additional","affiliation":[{"name":"Department of Consultation\u2010Liaison Psychiatry and Psychosomatic Medicine, University Hospital, Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3765-2040","authenticated-orcid":false,"given":"Annemarie","family":"Wentzel","sequence":"additional","affiliation":[{"name":"Hypertension in Africa Research Team (HART) North\u2010West University  Potchefstroom South Africa"},{"name":"South African Medical Research Council Unit for Hypertension and Cardiovascular Disease North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u2010S002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.104"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.06.012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2018.1557683"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp252"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291137"},{"key":"e_1_2_12_9_1","first-page":"370","article-title":"Zur dynamik des herzmuskels","volume":"32","author":"Frank O.","year":"1895","journal-title":"Zeitschrift Fur Biologie"},{"key":"e_1_2_12_10_1","first-page":"483","article-title":"Die Grundform des pulses","volume":"37","author":"Frank O.","year":"1899","journal-title":"Zentralblatt Fur Bakteriologie"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1988.255.6.H1443"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.03.003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00127"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1353\/book.3231"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872\u2010199917060\u201000001"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282fe1d28"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.01.001"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20102132"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.36.5.862"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040\u20103590.3.3.356"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00314"},{"key":"e_1_2_12_23_1","first-page":"235","volume-title":"Encyclopedia of Behavioral Medicine","author":"Hughes B. 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