{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:48:45Z","timestamp":1790927325158,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K24727"],"award-info":[{"award-number":["23K24727"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"Abstract<\/jats:title>\n \n The cold pressor test (CPT) is a clinical stress test commonly used to evoke acute pressor and respiratory responses, accompanied by increased sympathetic nerve activity. Cerebral blood flow (CBF) is well\u2010preserved during CPT despite elevated arterial blood pressure (ABP), but the underlying mechanisms remain unclear. We hypothesized that dynamic cerebral autoregulation (dCA) contributes to this CBF preservation, preventing overperfusion under stress\u2010induced hypertension. Thirty\u2010seven healthy volunteers performed CPT for 3\u2009min, while ABP, middle cerebral artery mean velocity (MCA V\n mean<\/jats:sub>\n ), and end\u2010tidal carbon dioxide partial pressure (P\n ET<\/jats:sub>\n CO\n 2<\/jats:sub>\n ) were measured. CPT significantly increased ABP (\n p<\/jats:italic>\n \u2009<\u20090.001) and decreased P\n ET<\/jats:sub>\n CO\n 2<\/jats:sub>\n (\n p<\/jats:italic>\n \u2009=\u20090.032), whereas MCA V\n mean<\/jats:sub>\n remained unchanged (\n p<\/jats:italic>\n \u2009=\u20090.976), resulting in a significant decrease in cerebrovascular conductance index (CVCi) (\n p<\/jats:italic>\n \u2009<\u20090.001). The CPT\u2010induced relative change in CVCi was significantly associated with the low\u2010frequency (LF) phase (\n p<\/jats:italic>\n \u2009<\u20090.001). Notably, the CPT\u2010induced decrease in P\n ET<\/jats:sub>\n CO\n 2<\/jats:sub>\n was significantly associated with the decreases in MCA V\n mean<\/jats:sub>\n (\n p<\/jats:italic>\n \u2009<\u20090.001) and in %CVCi (\n p<\/jats:italic>\n \u2009=\u20090.009). These findings suggest that dynamic cerebral autoregulation, as well as the respiratory response (change in P\n ET<\/jats:sub>\n CO\n 2<\/jats:sub>\n ), plays a key role in maintaining CBF during CPT\u2010induced elevations in ABP. Furthermore, individual differences in dCA and respiratory responses may account for variability in cerebrovascular responses to acute pressor stimuli.\n <\/jats:p>","DOI":"10.14814\/phy2.70813","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:24:15Z","timestamp":1773005055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of dynamic cerebral autoregulation of cerebral blood flow regulation during cold pressor test"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-6468","authenticated-orcid":false,"given":"Shigehiko","family":"Ogoh","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Toyo University Saitama Japan"},{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales Glamorgan UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanoko","family":"Ito","sequence":"additional","affiliation":[{"name":"Endowed Laboratory from the Sumitomo Electric Group CSR Foundation Nara Women's University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Kaji","sequence":"additional","affiliation":[{"name":"Graduate School of Humanities and Sciences Nara Women's University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Kunimatsu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Toyo University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinu","family":"Tatsuta","sequence":"additional","affiliation":[{"name":"Graduate School of Humanities and Sciences Nara Women's University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-2871","authenticated-orcid":false,"given":"Manabu","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Endowed Laboratory from the Sumitomo Electric Group CSR Foundation Nara Women's University Nara Japan"},{"name":"Faculty of Engineering Nara Women's University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00328.2024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1973.tb05436.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087529"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.05.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000248533.58693.c4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626425"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00224.2017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490130003001"},{"key":"e_1_2_10_11_1","first-page":"H544","article-title":"Effects of sympathetic nerves on cerebral vessels in dog, cat, and monkey","volume":"235","author":"Heistad D. D.","year":"1978","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281058"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1975.tb01289.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1994.11740219"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00573.2009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3181aa64d7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10558-007-9044-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221119760"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.5.H2162"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.4.0754"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(98)00075-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01021-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.56.662.818"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00261.2022"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00002.2013"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00112.2024"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-017-0021-7"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001274"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2011.01055.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12576-020-00732-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.268953"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(98)00163-5"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70813","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:59:03Z","timestamp":1773377943000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.14814\/phy2.70813"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70813","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70813"}}