{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:53:56Z","timestamp":1783947236076,"version":"3.55.0"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01BX000776"],"award-info":[{"award-number":["5I01BX000776"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX004249"],"award-info":[{"award-number":["I01BX004249"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6BX006040"],"award-info":[{"award-number":["IK6BX006040"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL171197"],"award-info":[{"award-number":["R01HL171197"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL142935"],"award-info":[{"award-number":["R01HL142935"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL162773"],"award-info":[{"award-number":["R01HL162773"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL172944"],"award-info":[{"award-number":["R01HL172944"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149677"],"award-info":[{"award-number":["R01HL149677"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD038119"],"award-info":[{"award-number":["S10OD038119"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG070188"],"award-info":[{"award-number":["R21AG070188"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cardiac afferent neurons have been shown to trigger overactivation of neurohormonal systems known to drive adverse cardiac remodeling following myocardial infarction (MI). Acid\u2010sensing ion channels (ASICs) that are highly expressed in cardiac sympathetic afferents sense ischemia\u2010induced myocardial acidosis. We hypothesized that genetic deletion of ASICs might abrogate disadvantageous remodeling after MI by disrupting afferent signaling pathways otherwise resulting in overactivation of neurohormonal responses. To test this, we induced MI in wild type (WT) and ASIC3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice and assessed cardiac remodeling by serial echocardiography. We found that ASIC3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had less LV dilation relative to ischemic zone fraction, increased LV mass and wall thickness, and increased stroke volume compared to WT mice after MI. To investigate a potential role of the autonomic nervous system, we measured renal and splanchnic sympathetic nerve activity (SNA), heart rate and systolic blood pressure variability (sBPV), and hemodynamic responses to atropine and propranolol. Following MI, ASIC3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had lower baroreceptor\u2010renal SNA reflex sensitivity than WT mice, associated with elevated sBPV. Our data show that ASIC3 plays an important role in cardiac remodeling after MI potentially via modulation of baroreflex sensitivity and sBPV. ASIC3 may be further investigated as a potential therapeutic target in heart failure.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70823","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:40:27Z","timestamp":1773214827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic deletion of\n                    <scp>ASIC3<\/scp>\n                    alters left ventricular remodeling and autonomic function after myocardial infarction in mice"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-4024","authenticated-orcid":false,"given":"Karley M.","family":"Monaghan","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"},{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad C.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram","family":"El\u2010Geneidy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Kutschke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy A.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-1903","authenticated-orcid":false,"given":"Harald M.","family":"Stauss","sequence":"additional","affiliation":[{"name":"Department of Health, Sport, and Human Physiology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie S.","family":"Harding","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"},{"name":"Veterans Affairs Health Care System  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C. M.","family":"Bader","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"},{"name":"Veterans Affairs Health Care System  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasna","family":"Sabharwal","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"},{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"},{"name":"Veterans Affairs Health Care System  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"},{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"},{"name":"Veterans Affairs Health Care System  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-8193","authenticated-orcid":false,"given":"Christopher J.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"},{"name":"Department of Internal Medicine University of Iowa  Iowa City Iowa USA"},{"name":"Veterans Affairs Health Care System  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.12.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.020297"},{"key":"e_1_2_10_4_1","first-page":"62","article-title":"Cardiac remodeling: Concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment","volume":"106","author":"Azevedo P. S.","year":"2016","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00488.2006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.8.921"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032678399"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.029"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f55"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-199505"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12447"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0490"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409273111303"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00476.2021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00677.2001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00274-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9055-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.202036"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.106122"},{"key":"e_1_2_10_20_1","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the Management of Heart Failure: A report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich P. A.","year":"2022","journal-title":"Circulation"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.24.2863"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.118349"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328333af48"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90869-X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24525-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-869"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06163"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.9.1163"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.6.R2214"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2018.12.001"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1054\/j.cardfail.2003.09.001"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.47.6.1174"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.12.020"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138933.85923.36"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1993.1017"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00459.2021"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.47.29778"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.007"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1969.217.3.703"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160921911"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00445.2004"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420949173"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.750696"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.1.136"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.357"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0857p.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.1.193"},{"key":"e_1_2_10_48_1","first-page":"H1406","article-title":"Progressive ventricular remodeling in rat with myocardial infarction","volume":"260","author":"Pfeffer J. M.","year":"1991","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.22.2192"},{"key":"e_1_2_10_50_1","first-page":"IV93","article-title":"Ventricular enlargement and reduced survival after myocardial infarction","volume":"75","author":"Pfeffer M. A.","year":"1987","journal-title":"Circulation"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.843144"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.093699"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00547-5"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00208.2012"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80147-7"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101211"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2024.08.062"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-013-0368-x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00917.2001"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00716.2006"},{"key":"e_1_2_10_61_1","first-page":"H776","article-title":"Modulation of baroreflex sensitivity and spectral power of blood pressure by heat stress and aging","volume":"272","author":"Stauss H. M.","year":"1997","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.711"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.25.2981"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.154377"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.206946"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1975.228.1.27"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00499-4"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-254623"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273764"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03699"},{"key":"e_1_2_10_71_1","first-page":"R751","article-title":"Cardiac sympathetic afferent reflex in dogs with congestive heart failure","volume":"271","author":"Wang W.","year":"1996","journal-title":"American Journal of Physiology"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.06.014"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.073"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.1.44"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.12.058"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000238388.79295.4c"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.71.2.460"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00288-1"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70823","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:58:52Z","timestamp":1773377932000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.14814\/phy2.70823"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70823","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70823"}}