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However, research is lacking on its effects on renal physiology. This study aimed to investigate the renal effects of short\u2010term exogenous ketosis in healthy adults, focusing on glomerular function and electrolyte handling. In a double\u2010blind, placebo\u2010controlled, randomized crossover trial, 15 healthy participants received ketone monoester (KME) or placebo three times daily for 5\u2009days under a standardized diet, separated by a 2\u2010week washout. On the fifth day of each intervention, participants collected a 24\u2010h urine sample. The following day, glomerular filtration rate (GFR) was assessed with\n                    <jats:sup>99m<\/jats:sup>\n                    Technetium\u2010diethylene\u2010triamine\u2010pentaacetate (Tc\u201099\u2010DTPA) clearance, and urinary electrolyte excretion was measured. Thirteen participants completed both treatment periods. Compared with placebo, KME treatment acutely increased GFR by 6.0\u2009mL\/min (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and sodium excretion increased by 69\u2009\u03bcmol\/min (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), while potassium excretion decreased (\u221231\u2009\u03bcmol\/min;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Electrolyte excretion measured in 24\u2010h urine remained unchanged. In conclusion, short\u2010term KME supplementation was associated with acute increases in measured GFR and urinary sodium excretion, while reducing urinary potassium excretion in healthy adults. No changes in electrolyte excretion were detectable in the 24\u2010h urine, indicating that renal effects are not sustained over the full collection period.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70829","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:02:16Z","timestamp":1773716536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Renal effects of short\u2010term ketone monoester supplementation in healthy adults: A randomized, placebo\u2010controlled study"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1318-3738","authenticated-orcid":false,"given":"Trine Z.","family":"Lyksholm","sequence":"first","affiliation":[{"name":"University Clinic in Nephrology and Hypertension, G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla L.","family":"Duus","sequence":"additional","affiliation":[{"name":"University Clinic in Nephrology and Hypertension, G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen F.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"University Clinic in Nephrology and Hypertension, G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Renal Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik H.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Medical Diagnostic Center University Clinic for Innovative Patient Pathways, Regional Hospital Central Jutland  Viborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper N.","family":"Bech","sequence":"additional","affiliation":[{"name":"University Clinic in Nephrology and Hypertension, G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00193.2023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00396.2011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18101436"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1609737"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067971"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/kidneydial2020020"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101283"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.114.4.561"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090430"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.06.031"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-2-331"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9812806"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V25949"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005066"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00616.2011"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"F447","article-title":"Direct analysis of the effector mechanism of the tubuloglomerular feedback system","volume":"243","author":"Ichikawa I.","year":"1982","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00141.2020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.10.5440"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1976.tb00496.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.800055"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2013.07.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00057.2024"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2012.702835"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1624639"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036459"},{"issue":"4","key":"e_1_2_10_27_1","first-page":"423","article-title":"The mechanisms by which sodium excretion is increased during a fast but reduced on subsequent carbohydrate feeding","volume":"46","author":"North K. 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