{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:55:11Z","timestamp":1777276511755,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["SFRN 863621"],"award-info":[{"award-number":["SFRN 863621"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18CDA34110323"],"award-info":[{"award-number":["18CDA34110323"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cardiovascular disease (CVD) is a leading cause of mortality in men with prostate cancer (PC), with non\u2010Hispanic Black (NHB) men experiencing disproportionately higher CVD\u2010related mortality compared to non\u2010Hispanic White (NHW) men. Vascular endothelial dysfunction precedes overt CVD; however, the mechanisms underlying racial disparities in CVD among men with PC remain unclear. This study tested the hypothesis that NHB men with PC would exhibit impaired vascular health compared to NHW men. Thirty\u2010four men (12 NHW and 22 NHB) with a clinical diagnosis of PC underwent comprehensive vascular assessment, including arterial stiffness (pulse wave velocity [PWV] and augmentation index at 75\u2009bpm [AIx75]), conduit\u2010vessel endothelial function (flow\u2010mediated dilation [FMD]), and microvascular function (post\u2010occlusive reactive hyperemia [PORH], local thermal heating [LTH], and acetylcholine iontophoresis). Clinical laboratory values, senescence\u2010associated secretory phenotype (SASP), and allostatic load were also evaluated. NHW men were older (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.050), with no differences in body mass index (BMI), laboratory values, allostatic load, or SASP (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). NHB men demonstrated significantly lower PORH, LTH, and acetylcholine responses (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while PWV, AIx75, and FMD were similar between groups. Despite comparable conduit\u2010vessel and arterial stiffness measures, NHB men exhibited impaired microvascular function, suggesting racial differences in vascular bed\u2010specific dysfunction following PC diagnosis.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70834","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:17:45Z","timestamp":1776489465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Racial disparity in microvascular function among non\u2010Hispanic white and non\u2010Hispanic black men with newly diagnosed prostate cancer"],"prefix":"10.14814","volume":"14","author":[{"given":"Abigayle B.","family":"Simon","sequence":"first","affiliation":[{"name":"Georgia Prevention Institute, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob C.","family":"Looney","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsha","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reva","family":"Crandall","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Thomas","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avirup","family":"Guha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha K.","family":"Terris","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal L.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Rodriguez\u2010Miguelez","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Sciences Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Division of Pulmonary and Critical Care, Department of Internal Medicine Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8826-681X","authenticated-orcid":false,"given":"Ryan A.","family":"Harris","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ab2651"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05244-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30115"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-022-01311-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahjo.2024.100382"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183653"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01397.2013"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2024.05.005"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199805000-00021"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.280"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150821"},{"key":"e_1_2_12_13_1","volume-title":"StatPearls","author":"Jain M. A.","year":"2024"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12658"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00728.2004"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-023-00258-1"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahjo.2024.100397"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz058"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.023"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013915"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.002154"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/heq.2019.0057"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax2342"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319811"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a030387"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.235119"},{"key":"e_1_2_12_28_1","first-page":"1977","article-title":"Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD","volume":"10","author":"Rodriguez\u2010Miguelez P.","year":"2015","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00136.2016"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2011.00129.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.05.007"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac247"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.058"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2022.10.004"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz766"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108116"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02185"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.127"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0030-z"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13059"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1119095"},{"issue":"3","key":"e_1_2_12_42_1","first-page":"291","article-title":"Endothelial dysfunction and cardiovascular disease","volume":"2014","author":"Widmer R. J.","year":"2014","journal-title":"Global Cardiology Science & Practice"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0712"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.864801"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.5340"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:11:13Z","timestamp":1777273873000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.14814\/phy2.70834"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70834","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70834"}}