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Although evidence suggests that isometric contractions can confer molecular and physiological benefits to DMD muscle, their impact on viscoelastic properties has not been assessed in\u00a0vivo. Given that DMD is characterized by muscular instability due to the absence of dystrophin, we employed \u201cmyomechanical profiling\u201d\u2014a custom apparatus compatible with an MCR702e rheometer\u2014to evaluate stiffness, compressibility, and elasticity of the tibialis anterior muscle of male mice following a bout of submaximal isometric fatiguing exercise. Fatigue was standardized to a 50% reduction in strength. Immediately after exercise, both dystrophin\u2010positive (wildtype) and dystrophin\u2010deficient (\n                    <jats:italic>mdx<\/jats:italic>\n                    ) muscles exhibited reduced compressibility. Storage and loss moduli, reflecting stiffness and energy dissipation during rotational deformation, increased markedly in fatigued wildtype muscle but remained unchanged in\n                    <jats:italic>mdx<\/jats:italic>\n                    muscle. Conversely, elasticity was unaffected in wildtype muscle but shifted\n                    <jats:italic>mdx<\/jats:italic>\n                    muscle toward a more viscous state. These findings indicate that compressibility, stiffness, and energy storage capacity are not disproportionately affected in dystrophin\u2010deficient muscle compared to wildtype muscle following fatiguing contractions. Thus, metabolically fatiguing, non\u2010lengthening contractions appear not to compromise viscoelastic properties in dystrophin\u2010deficient muscle, supporting their potential clinical use without exacerbating muscle instability.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70841","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:44:58Z","timestamp":1773981898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Viscoelastic properties of dystrophin\u2010deficient mouse skeletal muscles are resilient to isometric fatiguing exercise"],"prefix":"10.14814","volume":"14","author":[{"given":"Deirdre L.","family":"Merry","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Canterbury  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavithran","family":"Devananthan","sequence":"additional","affiliation":[{"name":"Biomolecular Interaction Centre University of Canterbury  Christchurch New Zealand"},{"name":"Department of Mechanical Engineering University of Canterbury  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Kabaliuk","sequence":"additional","affiliation":[{"name":"Biomolecular Interaction Centre University of Canterbury  Christchurch New Zealand"},{"name":"Department of Mechanical Engineering University of Canterbury  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-1901","authenticated-orcid":false,"given":"Angus","family":"Lindsay","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Canterbury  Christchurch New Zealand"},{"name":"Biomolecular Interaction Centre University of Canterbury  Christchurch New Zealand"},{"name":"Department of Medicine University of Otago  Christchurch New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IRBM.2014.11.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NMD.2025.106217"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010020\u201001430\u20108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00492.2025"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/JCEM\u201060\u20102\u2010320"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/JRM.V53.985"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/RSPB.1992.0058"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90579-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.14814\/PHY2.13374"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/FJ.03\u20100453COM"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24445"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36612"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05721"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395\u2010020\u20100221\u20102"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy404"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13627"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00948.2018"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14831"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPCELL.00155.2019"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/MUS.27137"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00121296"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002080"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JELEKIN.2007.11.005"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.128.3.355"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3710"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NMD.2018.02.007"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.239"},{"key":"e_1_2_12_29_1","unstructured":"Reuters. 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