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Such remodeling requires modification of chromatin structure to support transcriptional activation and repression of gene programs. Chromatin dynamics depend, in part, on the acetylation and methylation of histone 3 lysine 27 (H3K27), which is controlled by several enzymes that add and remove these histone marks. Several histone post\u2010translational modifications in muscle have been shown to be modulated by exercise. Here, we sought to examine whether major H3K27 regulators themselves are altered by endurance training. Male and female C57BL\/6J mice were provided with voluntary running wheels for 6\u2009weeks and compared to sex\u2010matched sedentary controls with locked running wheels. We found that exercise altered gene expression of epigenetic machinery responsible for regulating acetylation and methylation enrichment in both a muscle\u2010 and sex\u2010specific manner, including major H3K27 acetyltransferases and core components of the polycomb repressive complex\u20102. Our findings add to a growing body of evidence implicating H3K27 post\u2010translational modifications, and thereby chromatin dynamics, as a mechanistic component of exercise\u2010induced muscle remodeling.<\/jats:p>","DOI":"10.14814\/phy2.70853","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:04:36Z","timestamp":1774847076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010 and skeletal muscle\u2010specific gene expression response of histone 3 lysine 27\u2010modifying enzymes by voluntary running in mice"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7311-8008","authenticated-orcid":false,"given":"Daniel","family":"Gamu","sequence":"first","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makenna","family":"Cameron","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1282-1084","authenticated-orcid":false,"given":"Yasmeen","family":"Jalil","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2288-3031","authenticated-orcid":false,"given":"Imen","family":"Zouaoui","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jada","family":"Sangha","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84618"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.03.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.12.008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009907"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000183179.86594.4f"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00694.2005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2022"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0548"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"Gamu D. 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