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This study aimed to investigate the regulatory effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S on the PERK\/TXNIP\/NLRP3 pathway and the paraventricular nucleus (PVN) inflammatory responses by injecting S\u2010adenosylmethionine (SAMe, an endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S agonist) or the PERK inhibitor GSK2606414 (GSK) into the PVN of spontaneously hypertensive rats (SHR). Additionally, we employed a lipopolysaccharide (LPS)\u2010induced cell inflammation model and intervened with SAMe or the NLRP3 activator BMS\u2010986299 (BMS) to further validate the relevant molecular mechanisms. Relevant indicators were analyzed using tail artery blood pressure measurement, CCK\u20108 assay, ELISA, immunofluorescence, western blot, and real\u2010time quantitative polymerase chain reaction (RT\u2010qPCR). This study found that H\n                    <jats:sub>2<\/jats:sub>\n                    S in the PVN improves spontaneous hypertension by inhibiting the PERK\/TXNIP\/NLRP3 pathway and reducing sympathetic activity. Cell experiments further confirmed that the inhibitory effect of H\n                    <jats:sub>2<\/jats:sub>\n                    S on this pathway is the key mechanism underlying its anti\u2010inflammatory protective effects.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70861","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:11:41Z","timestamp":1775887901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanism of paraventricular nucleus\n                    <scp>\n                      H\n                      <sub>2<\/sub>\n                      S\n                    <\/scp>\n                    on\n                    <scp>PERK<\/scp>\n                    \/\n                    <scp>TXNIP<\/scp>\n                    \/\n                    <scp>NLRP3<\/scp>\n                    pathway in male spontaneously hypertensive rats"],"prefix":"10.14814","volume":"14","author":[{"given":"Yan\u2010Feng","family":"Liang","sequence":"first","affiliation":[{"name":"School of Basic Medicine Jiamusi University  Jiamusi China"},{"name":"Key Laboratory of Microecology\u2010Immune Regulatory Network and Related Diseases School of Basic Medicine Jiamusi University  Jiamusi China"},{"name":"Provincial Demonstration Center for Experimental Teaching of Basic Medicine Jiamusi University  Jiamusi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Jiamusi University  Jiamusi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Jiamusi University  Jiamusi 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