{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:15Z","timestamp":1785214815298,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23DIVSUP1066372"],"award-info":[{"award-number":["23DIVSUP1066372"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["5T32GM141862\u201002"],"award-info":[{"award-number":["5T32GM141862\u201002"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["9T37\u2010MD001480"],"award-info":[{"award-number":["9T37\u2010MD001480"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increases in body mass are associated with the development of metabolic dysfunction\u2010associated steatotic liver disease (MASLD). Caloric restriction (CR) is the primary non\u2010pharmacological defense against MASLD; however, poor CR maintenance induces partial body mass regain (PR), leading to MASLD progression. We conducted an in\u00a0vivo study to investigate the effects of PR following 2\u2009weeks of CR on the hepatic lipidome during Metabolic Syndrome (MetS) using the male Otsuka Long Evans Tokushima Fatty (OLETF) rat and the Long Evans Tokushima Otsuka (LETO) rat as strain control (Ctrl). PR reduced hepatic acyl\u2010CoA oxidase 1 (ACOX1) and carnitine palmitoyl transferase II (CPT2) protein expression compared to OLETF CR. The lipidome indicated that PR maintained reduced total TAGs primarily MUFA and PUFA TAGs, while SFA\u2010TAGs were elevated. Additionally, OLETF PR demonstrated a negative correlation with cholesteryl ester and an elevation in HDL levels vs. OLETF CR. These findings suggest that PR may promote hepatic steatosis by reducing fatty acid utilization and potentially associated with dysfunctional HDL, which can induce hepatic inflammation and injury. This study highlights the detriments of PR during MetS, suggesting that careful health monitoring is necessary for individuals with compromised metabolism when using dietary interventions to ameliorate MASLD.<\/jats:p>","DOI":"10.14814\/phy2.70865","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:32:13Z","timestamp":1781677933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Partial body mass regain attenuates lipid utilization and alters the hepatic lipidome linked to\n                    <scp>HDL<\/scp>\n                    dysfunction during metabolic syndrome in male rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-2665","authenticated-orcid":false,"given":"Eira E.","family":"Jardines","sequence":"first","affiliation":[{"name":"School of Natural Sciences University of California  Merced California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-8674","authenticated-orcid":false,"given":"Manuel A.","family":"Cornejo","sequence":"additional","affiliation":[{"name":"School of Natural Sciences University of California  Merced California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Newman","sequence":"additional","affiliation":[{"name":"Western Human Nutrition Research Center, Agricultural Research Service United States Department of Agriculture  Davis California USA"},{"name":"Department of Nutrition University of California\u2010Davis  Davis California USA"},{"name":"West Coast Metabolomics Center, UC Davis Genome Center University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Fiehn","sequence":"additional","affiliation":[{"name":"West Coast Metabolomics Center, UC Davis Genome Center University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy M.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"School of Natural Sciences University of California  Merced California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm\u20102012\u20100261"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510080071034"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01221"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20103111"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac321"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8723460"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46658"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00363"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.01.022"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10080960"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20100500\u20105\u2010513"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803510200"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23621"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201047"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010019\u201001633\u20102"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b05592"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142727.mb3004s114"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21538"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010021\u201002834\u20107"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048852"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx012"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.11.013"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910303"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802556075"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00089.2016"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.02.030"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11\u20100378"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201099"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.122978"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102275(20)32007\u20101"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21763"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.7.915"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2010"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010019\u20100984\u20109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R300017200"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44442"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011\u20101885"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23256"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.44.809"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021979"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179226"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121434"},{"key":"e_1_2_12_46_1","first-page":"688","article-title":"Treatment of Obesity by Moderate and Severe Caloric Restriction: Results of Clinical Research Trials","volume":"119","author":"Thomas A.","year":"2000","journal-title":"Annals of Internal Medicine"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.01.026"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100035\u20101"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.24875\/GMM.M18000092"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.01.011"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2019.05.002"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D800028\u2010JLR200"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1366479"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387\u2010018\u20100045\u2010x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010021\u201001457\u20101"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70865","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:28:13Z","timestamp":1785212893000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.14814\/phy2.70865"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70865","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70865"}}