{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:55:37Z","timestamp":1777276537012,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20230703"],"award-info":[{"award-number":["20230703"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The long QT syndrome type 1 (LQT1) is caused by loss\u2010of\u2010function mutations affecting the potassium channel current I\n                    <jats:sub>Ks<\/jats:sub>\n                    important for repolarization adaptation at heart rate (HR) increase. We therefore compared changes in three global VR dispersion parameters following a rapid, atropine\u2010induced HR increase in LQT1 patients versus healthy controls applying Frank vectorcardiography. The adaptation patterns, magnitudes, and changing rates of T amplitude, T area, and the ventricular gradient were assessed during 5\u2009min following injection. Twenty\u2010one LQT1 patients and 31 controls were enrolled. HR increased similarly within ~23\u2009s. The majority had a tri\u2010phasic VR dispersion adaptation pattern: a rapid decrease to a minimum, a slower return to a slightly higher level, and a very slow almost horizontal decrease. In the LQT1 group, all three dispersion parameters had a longer lasting rapid phase and larger overshoot reaction, although statistically significant only for T amplitude. In conclusion, LQT1 was associated with an augmented adaptation of global dispersion parameters to a rapid HR increase versus healthy controls. Further studies are needed to determine how these observations relate to arrhythmogenesis and if the atropine test of QT interval and dispersion adaptation can be used in risk assessment on the individual level.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70889","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T02:39:01Z","timestamp":1777257541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>LQT1<\/scp>\n                    patients have augmented response of repolarization dispersion following atropine induced heart rate increase versus healthy controls"],"prefix":"10.14814","volume":"14","author":[{"given":"Pia","family":"Dahlberg","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Jonas","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen M.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Heart Centre Ume\u00e5 University Hospital  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunilla","family":"Lundahl","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Gransberg","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-9388","authenticated-orcid":false,"given":"Lennart","family":"Bergfeldt","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"issue":"17","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1113\/jphysiol.2013.254920","article-title":"Long QT syndrome: Beyond the causal mutation","volume":"591","author":"Amin A. 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