{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:10Z","timestamp":1783836430568,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigated the middle (MCAv) and posterior (PCAv) cerebral artery blood velocity and end\u2010tidal carbon dioxide (P\n                    <jats:sub>ET<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    ) responses during sprint interval exercise (SIE). We also examined the relationships between MCAv, PCAv and blood pressure during the 60\u2009min post SIE. Fourteen healthy adults completed four 30\u2009s maximal cycle sprints, each separated by 4\u2009min of unloaded cycling. MCAv and PCAv demonstrated a rapid increase followed by a return towards the initial baseline values during each sprint. The increase during the first sprint (MCAv: +31.9%\u2009\u00b1\u200919.9%, PCAv: +32.5%\u2009\u00b1\u200930.6%) was always greater than subsequent sprints (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.039). Each sprint was followed by a transient increase in MCAv and PCAv, which mirrored P\n                    <jats:sub>ET<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    . SIE was followed by 60\u2009min of hypocapnia, and blood pressure was significantly lowered 10\u201320 and 40\u201355\u2009min post SIE. However, resting MCAv was not altered, and PCAv was only lower 5\u2009min post SIE. Resting MCAv phase and gain, and PCAv phase were largely unaltered apart from the first 5\u2009min post SIE. The ability to buffer changes in blood pressure during repeated squat\u2010stand maneuvers remained intact 60\u2009min post SIE, although a greater fall in MCAv and PCAv was noted during a single sit\u2010to\u2010stand transition at this time.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70901","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:14:34Z","timestamp":1777702474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral blood velocity responses during and after sprint interval exercise in healthy young adults"],"prefix":"10.14814","volume":"14","author":[{"given":"E.","family":"Scott","sequence":"first","affiliation":[{"name":"The Vascular Research Group, Public Health and Sport Sciences University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Langson\u2010Justice","sequence":"additional","affiliation":[{"name":"The Vascular Research Group, Public Health and Sport Sciences University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Smail","sequence":"additional","affiliation":[{"name":"The Vascular Research Group, Public Health and Sport Sciences University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Lester","sequence":"additional","affiliation":[{"name":"The Vascular Research Group, Public Health and Sport Sciences University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"The Vascular Research Group, Public Health and Sport Sciences University of Exeter  Exeter UK"},{"name":"Federal University of Rio Grande Do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J. A.","family":"Pugh","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Research, Innovation and Development Cardiff Metropolitan University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-6512","authenticated-orcid":false,"given":"M. E.","family":"Weston","sequence":"additional","affiliation":[{"name":"The Vascular Research Group, Public Health and Sport Sciences University of Exeter  Exeter UK"},{"name":"THRIVE Laboratory, Department of Physiology, School of Medicine Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3597-8562","authenticated-orcid":false,"given":"B. O.","family":"Bond","sequence":"additional","affiliation":[{"name":"The Vascular Research Group, Public Health and Sport Sciences University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00035.2017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00854.2014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.060178"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018478"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00790.2016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-023-00986-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.142109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14367"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17691986"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0119-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00051.2002"},{"issue":"2","key":"e_1_2_9_16_1","first-page":"65","article-title":"Mechanisms and clinical implications of post\u2010exercise hypotension in humans","volume":"29","author":"Halliwill J. R.","year":"2001","journal-title":"Exercise and Sport Sciences Reviews"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005293"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-008-0797-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-020-00421-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001924"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-005-0249-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.30"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14430"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13984"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.49"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00175.2008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP085143"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.179549"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00573.2009"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510008"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2007.01708.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00948.2004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00801.2006"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221119760"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01348.2005"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00106.2016"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00069.2008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.269"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00543.2023"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.204461"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.230425"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00020.2002"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15676"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00264.2015"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2016.06.007"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086249"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01657"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.3.954"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2011.01320.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00328.2012"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.609935"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.323049"},{"key":"e_1_2_9_54_1","first-page":"214","article-title":"The effect of exercise intensity and cardiorespiratory fitness on the kinetic response of middle cerebral artery blood velocity during exercise in adults","volume":"2022","author":"Weston M. E.","year":"1985","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00182.2021"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00862.2021"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70550"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00772.2021"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00635.2023"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00484.2021"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-012-2578-3"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.011"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.268953"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70901","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:11:59Z","timestamp":1783833119000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.14814\/phy2.70901"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70901","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70901"}}