{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:18Z","timestamp":1783836438458,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD094602"],"award-info":[{"award-number":["HD094602"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6 RX003351"],"award-info":[{"award-number":["IK6 RX003351"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Skeletal muscles are exquisitely designed to produce force that facilitate movement. Circadian \u201cmolecular clocks\u201d residing in muscle play a role in regulating force production with muscle stem cell (\n                    <jats:italic>satellite cells<\/jats:italic>\n                    ,\n                    <jats:italic>SC)<\/jats:italic>\n                    molecular clocks modulating isometric and eccentric force according to time\u2010of\u2010day. However, many tasks of daily living and exercise (i.e., walking\/running) involve force and power produced during muscle shortening. Thus, the purpose of this study was to determine whether isovelocity forces and power are also modulated by SCs according to time\u2010of\u2010day. Using previously published samples (a mouse model capable of SC ablation), we evaluated isovelocity forces across a range of velocities (1\u201311 L\n                    <jats:sub>f<\/jats:sub>\n                    \/s) at two different times of day ZT1, ZT9 in the presence and absence of SCs. The main finding of this investigation was that isovelocity force production is regulated by a third\u2010order interaction effect between time\u2010of\u2010day \u00d7 SCs \u00d7 velocity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Additionally, a significant effect of time\u2010of\u2010day was observed for isovelocity force and power when comparing ZT1 vs. ZT9 SC\n                    <jats:sup>+<\/jats:sup>\n                    mice whereas this effect was absent in SC\n                    <jats:sup>\u2212<\/jats:sup>\n                    animals. These results suggest SCs harbor a time\u2010of\u2010day and velocity dependent effect on isovelocity force production and power. Further work is required to elucidate the underlying mechanisms of this phenomenon.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70902","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:11:06Z","timestamp":1777867866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010of\u2010day, satellite cells, and velocity collectively influence ex\u00a0vivo isovelocity force production in mouse extensor digitorum longus muscle"],"prefix":"10.14814","volume":"14","author":[{"given":"Ryan E.","family":"Kahn","sequence":"first","affiliation":[{"name":"Shirley Ryan AbilityLab  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-0497","authenticated-orcid":false,"given":"Sudarshan","family":"Dayanidhi","sequence":"additional","affiliation":[{"name":"Shirley Ryan AbilityLab  Chicago Illinois 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