{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:28Z","timestamp":1785214828810,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Short\u2010term high\u2010fat diet (HFD) feeding is used to study metabolic dysregulation, yet many rodent models use extreme fat contents that may not reflect physiological conditions. Skeletal muscle responses to short\u2010term HFD also vary by muscle type. We tested whether a physiologically relevant HFD induces muscle\u2010type\u2013specific changes in skeletal muscle signaling and mitochondrial\u2010related proteins. Male Wistar rats were fed a low\u2010fat diet (LFD; 10% energy from fat) or HFD (40% energy from fat) for 4\u2009weeks (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095\/group). Soleus and extensor digitorum longus (EDL) muscles were analyzed for OXPHOS complexes, mitochondrial dynamics proteins, and ERK1\/2 signaling. HFD increased energy intake and visceral adiposity without changing body weight or muscle mass. In soleus, OXPHOS complex II was reduced, whereas other complexes were preserved. In EDL, phosphorylation of ERK1\/2 (Thr202\/Tyr204) and Drp1 (Ser616) was reduced without changes in total protein abundance. Thus, short\u2010term, physiologically relevant HFD feeding induces muscle\u2010type\u2013specific molecular and signaling adaptations before overt changes in body weight or muscle mass.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70904","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:10:48Z","timestamp":1781583048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010term high\u2010fat feeding induces muscle\u2010type\u2013specific signaling adaptations in skeletal muscle of male rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5545-8022","authenticated-orcid":false,"given":"Arata","family":"Tsutaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-7063","authenticated-orcid":false,"given":"Hidetaka","family":"Imagita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3577-8180","authenticated-orcid":false,"given":"Asumi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health Sagami Women's University  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01327"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140179"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.608"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15\u2010276337"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.651211"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01064.2013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.01.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.08.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.230185"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13548"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c190029"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001593RR"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2017.41.5.327"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00422"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010019\u20100363\u20107"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123650"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607279200"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.230"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010013\u20102913\u20101"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112434"}],"container-title":["Physiological 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