{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:36Z","timestamp":1783840116500,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013704","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Paraguay","doi-asserted-by":"publisher","award":["CONACyT\u2010221262"],"award-info":[{"award-number":["CONACyT\u2010221262"]}],"id":[{"id":"10.13039\/501100013704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013704","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Paraguay","doi-asserted-by":"publisher","award":["CVU\u2010452329"],"award-info":[{"award-number":["CVU\u2010452329"]}],"id":[{"id":"10.13039\/501100013704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Arginine vasopressin is primarily recognized as an osmoregulatory hormone; however, its contribution to vascular tone and blood pressure regulation under basal and hypertensive conditions remains debated. This study examined the effects of vasopressin deficiency induced by neurointermediate pituitary lobectomy in Wistar and spontaneously hypertensive rats, compared with sham\u2010operated controls. Water intake, urine output, plasma vasopressin and oxytocin levels, blood pressure, and heart rate were evaluated over time. Neurointermediate pituitary lobectomy produced transient diabetes insipidus followed by the restoration of water balance, while plasma vasopressin and oxytocin levels remained markedly reduced at 3\u2010 and 90\u2010days post\u2010surgery (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001 vs. Sham). This deficiency was associated with sustained hypotension in Wistar rats (~27\u2009mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and normalized systolic blood pressure in spontaneously hypertensive rats (~50\u2009mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Acute and chronic vasopressin and oxytocin deficiency causes transient diabetes insipidus, persistent hypotension in normotensive rats, and attenuated hypertension in spontaneously hypertensive rats with unchanged heart rate, demonstrating that vasopressin plays a key role in regulating both basal and hypertensive blood pressure.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70912","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:03:27Z","timestamp":1780038207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pituitary\n                    <i>Neurolobectomy<\/i>\n                    induces sustained hypotension in male Wistar rats and normalizes blood pressure in male spontaneously hypertensive rats"],"prefix":"10.14814","volume":"14","author":[{"given":"Gloria Marcela","family":"Villanueva\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda. Centro de Ciencias B\u00e1sicas Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma A.","family":"Bobadilla","sequence":"additional","affiliation":[{"name":"Departamento de Nefrolog\u00eda y Metabolismo Mineral Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, M\u00e9xico, e Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Luis","family":"Quintanar","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda. Centro de Ciencias B\u00e1sicas Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Ver\u00f3nica","family":"Rivera\u2010Cerecedo","sequence":"additional","affiliation":[{"name":"Bioterio. Instituto de Fisiolog\u00eda Celular (IFC) Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Roberto","family":"Chavira\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Hormonas Esteroides Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n  Mexico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalman","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Laboratory Medicine St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-080X","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Quintanar\u2010Stephano","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda. 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