{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:18Z","timestamp":1785214818944,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100023000","name":"Yenepoya University","doi-asserted-by":"publisher","award":["YU\/Seed Grant\u2010131\u20102022"],"award-info":[{"award-number":["YU\/Seed Grant\u2010131\u20102022"]}],"id":[{"id":"10.13039\/100023000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with excessive accumulation of extracellular matrix (ECM) components, which leads to disrupted lung architecture and respiratory failure. Interleukin (IL)\u201017 signaling induces fibrosis through inflammation; however, specific roles of its receptors IL\u20101RA and IL\u201017RC in fibrinolysis and ECM remodeling remain unclear. We hypothesized that inhibition of either IL\u201017RA or IL\u201017RC could reduce fibrosis by regulating MMP expression and function. In this study, a Bleomycin (BLM)\u2010induced murine model of pulmonary fibrosis was used to study the effect of neutralization of IL\u201017RA and IL\u201017RC on ECM remodeling, MMPs, and the fibrinolytic system. Fibrotic lungs showed increased levels of MMP\u20102 and MMP\u20109, corresponding with elevated expression of fibronectin and collagen. Neutralization of either IL\u201017RA or IL\u201017RC significantly reduced the expression of MMPs, activation of NF\u2010\u03baB, and restored normal fibrinolytic activity by upregulating uPA and downregulating PAI\u20101 levels.<\/jats:p>","DOI":"10.14814\/phy2.70913","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:12:47Z","timestamp":1781583167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>IL<\/scp>\n                    \u201017\n                    <scp>RA<\/scp>\n                    \/\n                    <scp>RC<\/scp>\n                    blockade modulates the fibrinolytic system and\n                    <scp>MMP<\/scp>\n                    activity in bleomycin\u2010induced pulmonary fibrosis in male mice"],"prefix":"10.14814","volume":"14","author":[{"given":"Rakshitha","family":"Charavu","sequence":"first","affiliation":[{"name":"Cell Biology &amp; Molecular Genetics Division, Yenepoya Research Centre Yenepoya Deemed to Be University  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeena Thrikkandiyoor","family":"Madambath","sequence":"additional","affiliation":[{"name":"Cell Biology &amp; Molecular Genetics Division, Yenepoya Research Centre Yenepoya Deemed to Be University  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akarsha B.","family":"Jain","sequence":"additional","affiliation":[{"name":"Cell Biology &amp; Molecular Genetics Division, Yenepoya Research Centre Yenepoya Deemed to Be University  Mangalore Karnataka India"},{"name":"Cell and Molecular Biology The University of Texas Health Science Centre  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-3561","authenticated-orcid":false,"given":"Yashodhar P.","family":"Bhandary","sequence":"additional","affiliation":[{"name":"Cell Biology &amp; Molecular Genetics Division, Yenepoya Research Centre Yenepoya Deemed to Be University  Mangalore Karnataka India"},{"name":"Specialised Research Unit, Yenepoya Medical College &amp; Hospital Yenepoya Deemed to be University  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010022\u201002105\u20107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307892"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201410-448MG"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.11.012"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-007-8014-9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700289R"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00928.2007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00008414"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.229997"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21474"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.02.023"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111554"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.779534"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023185"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085461"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.012062"},{"issue":"11","key":"e_1_2_12_18_1","first-page":"S195","article-title":"Overview of idiopathic pulmonary fibrosis, evidence\u2010based guidelines, and recent developments in the treatment landscape","volume":"25","author":"Glassberg M. 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