{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:34Z","timestamp":1783840114513,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests increased NO promotes natriuresis, whereas inorganic nitrate studies remain inconclusive. We conducted a randomized, double\u2010blind, placebo\u2010controlled crossover trial in 18 healthy adults, with 4\u2009days of potassium nitrate (KNO\n                    <jats:sub>3<\/jats:sub>\n                    ) or placebo before 1\u2009L isotonic saline infusion. BP, hemodynamic markers of the NO system, and renal function were measured. After saline GFR, renal water and sodium handling did not significantly differ between KNO\n                    <jats:sub>3<\/jats:sub>\n                    and placebo (KCl). Central diastolic BP was modestly higher during KNO\n                    <jats:sub>3<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Brachial systolic BP did not differ (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.052); however, systolic BP was higher during KNO\n                    <jats:sub>3<\/jats:sub>\n                    after 120\u2009min (Sidak adjusted,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.030). Plasma levels of the second messenger of NO, cyclic guanosine monophosphate (cGMP), were lower after saline during KNO\n                    <jats:sub>3<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). Short\u2010term KNO\n                    <jats:sub>3<\/jats:sub>\n                    did not induce a natriuretic response during acute saline loading. KNO\n                    <jats:sub>3<\/jats:sub>\n                    was associated with a small increase in central diastolic BP and lower plasma cGMP levels. These findings suggest that high\u2010dose KNO\n                    <jats:sub>3<\/jats:sub>\n                    exposure may affect the endogenous NO response.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70919","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:25:21Z","timestamp":1780557921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-6852","authenticated-orcid":false,"given":"A. M.","family":"\u00d8stergaard","sequence":"first","affiliation":[{"name":"University Clinic in Nephrology and Hypertension G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Rosenb\u00e6k","sequence":"additional","affiliation":[{"name":"University Clinic in Nephrology and Hypertension G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Ejlersen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"Mose","sequence":"additional","affiliation":[{"name":"University Clinic in Nephrology and Hypertension G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N.","family":"Bech","sequence":"additional","affiliation":[{"name":"University Clinic in Nephrology and Hypertension G\u00f8dstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Vrist","sequence":"additional","affiliation":[{"name":"University Clinic in Nephrology and Hypertension G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-100"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2023.02.024"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13443"},{"issue":"5","key":"e_1_2_13_5_1","first-page":"F845","article-title":"Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans","volume":"270","author":"Bech J. 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Effect of furosemide on body composition and urinary proteins that mediate tubular sodium and sodium transport\u2014A randomized controlled trial 8.","DOI":"10.14814\/phy2.14653"},{"issue":"3","key":"e_1_2_13_12_1","first-page":"242","article-title":"Role of nitric oxide in renal hemodynamics","volume":"19","author":"Gabbai F. 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