{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:08:07Z","timestamp":1784005687730,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012806","name":"High Point University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Berberine has been shown to lower core temperature and heart rate during passive heat stress in animal models. This study evaluated the effect of dietary berberine supplementation on physiological and perceptual responses to exercise\u2010heat stress in humans. Eight participants (6 men\/2 women; Age: 23\u2009\u00b1\u20093\u2009years, Stature: 1.75\u2009\u00b1\u20090.03\u2009m, Mass: 71.8\u2009\u00b1\u20092.7\u2009kg, VO\n                    <jats:sub>2max<\/jats:sub>\n                    : 57.5\u2009\u00b1\u20092.1\u2009mL\/kg lbm\/min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) ingested 1.5\u2009g of Berberine or Placebo for 7d prior to a 1\u2009h treadmill run (60% VO\n                    <jats:sub>2max<\/jats:sub>\n                    ) in hot (35\u00b0C), moderately humid (39% RH) conditions. Mean body temperature (T\n                    <jats:sub>b<\/jats:sub>\n                    ), heart rate (HR), expired gasses (VO\n                    <jats:sub>2<\/jats:sub>\n                    , VCO\n                    <jats:sub>2<\/jats:sub>\n                    , RER), minute ventilation, respiratory rate (R\n                    <jats:sub>R<\/jats:sub>\n                    ), tidal volume, and perceptual responses (thermal sensation, perceived discomfort, and perceived exertion) were measured throughout exercise. Data are reported as average\u2009\u00b1\u2009standard deviation over the 60\u2009min exercise trial. T\n                    <jats:sub>b<\/jats:sub>\n                    was lower (p\u2009=\u20090.030) in Berberine (37.69\u2009\u00b1\u20090.53\u00b0C) than Placebo (37.84\u2009\u00b1\u20090.38\u00b0C). Heart rate was lower (p\u2009=\u20090.025) in Berberine (163\u2009\u00b1\u200928\u2009bpm) than Placebo (166\u2009\u00b1\u200930\u2009bpm). R\n                    <jats:sub>R<\/jats:sub>\n                    was lower (p\u2009=\u20090.045) in Berberine (38.8\u2009\u00b1\u200911.2\u2009bpm) than Placebo (41.4\u2009\u00b1\u200910.6\u2009bpm). Thermal sensation was lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) in Berberine (9.5\u2009\u00b1\u20094.2) than Placebo (12.3\u2009\u00b1\u20095.0). Generalized discomfort was lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.044) in Berberine (9.3\u2009\u00b1\u20095.1) than Placebo (12.1\u2009\u00b1\u20095.6). Perceived exertion was lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in Berberine (11.4\u2009\u00b1\u20093.4) than Placebo (13.1\u2009\u00b1\u20094.0). Dietary berberine supplementation improved mean body temperature, heart rate, respiratory rate, and perceptual responses during exertional heat stress. Many of these changes were of small magnitude, calling into question the potential utility of dietary berberine supplementation for work or exercise in hot ambient conditions.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70937","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:59:18Z","timestamp":1779944358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary berberine supplementation improves select physiological and psychological responses during exertional heat stress: A pilot study in young adults"],"prefix":"10.14814","volume":"14","author":[{"given":"Dante A.","family":"Van Arman","sequence":"first","affiliation":[{"name":"Department of Exercise Science High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Exercise Science High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw O.","family":"Korankyi","sequence":"additional","affiliation":[{"name":"Department of Exercise Science High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson P.","family":"Heckler","sequence":"additional","affiliation":[{"name":"Department of Exercise Science High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Occupational and Thermal Physiology, Centre for Physical Activity, Sport and Exercise Sciences Coventry University  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor L.","family":"Gillum","sequence":"additional","affiliation":[{"name":"Department of Kinesiology California Baptist University  Riverside California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-786X","authenticated-orcid":false,"given":"Matthew R.","family":"Kuennen","sequence":"additional","affiliation":[{"name":"Department of Exercise Science High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.08.032"},{"issue":"2","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2340\/1650197719702239298","article-title":"Perceived exertion as an indicator of somatic stress","volume":"2","author":"Borg G.","year":"1970","journal-title":"Scandinavian Journal of Rehabilitation 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