{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:35Z","timestamp":1783840115946,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonists elicit cardiovascular and renal protection. In humans, GLP\u20101 reduces plasma angiotensin II (ANGII) and increases renal perfusion, leading to increased natriuresis. The mechanisms underlying suppression of ANGII remain unclear but may involve ACE2 activation and\/or a decrease in angiotensinogen. To address this hypothesis, we performed post\u2010hoc analyses on stored arterial plasma samples from a published study. The study used a randomized, placebo\u2010controlled cross\u2010over design in which eight healthy male adults ingested a sodium\u2010standardized diet for 4\u2009days to reach steady state. Participants were examined during a 3\u2010h infusion of GLP\u20101 (1.5\u2009pmol\/kg\/min) or vehicle concurrent with an intravenous infusion of 0.9% NaCl (750\u2009mL\/h) to expand the extracellular volume. As previously published, GLP\u20101 infusion significantly increased urinary sodium excretion, and plasma ANGII concentrations decreased significantly only during GLP\u20101 infusion. The present analyses demonstrated that plasma angiotensinogen and ACE concentrations decreased similarly (parallel to renin concentrations) during GLP\u20101 and vehicle. Plasma ACE2 and Ang\u2010(1\u20137) peptide concentrations remained unchanged during infusions of saline with and without GLP\u20101. In conclusion, the acute ANGII\u2010lowering effect of GLP\u20101 does not depend on changes in circulating concentrations of angiotensinogen, ACE, ACE2, or Ang\u2010(1\u20137). Changes in enzyme activities independent of concentrations cannot be excluded.<\/jats:p>","DOI":"10.14814\/phy2.70940","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:30:51Z","timestamp":1780727451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute\n                    <scp>GLP<\/scp>\n                    \u20101 infusion in male adults lowers circulating angiotensin\n                    <scp>II<\/scp>\n                    without changing angiotensinogen,\n                    <scp>ACE<\/scp>\n                    ,\n                    <scp>ACE2<\/scp>\n                    , or angiotensin\u2010(1\u20137) concentrations"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-827X","authenticated-orcid":false,"given":"Ali","family":"Asmar","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital University Hospital of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muskaan","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital University Hospital of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-3125","authenticated-orcid":false,"given":"Charlotte M.","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper K.","family":"Andresen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research, Institute of Molecular Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boye L.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research, Institute of Molecular Medicine University of Southern Denmark  Odense 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