{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:05:38Z","timestamp":1779951938163,"version":"3.53.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Weight\u2010bearing and high\u2010impact exercise during growth enhance bone accrual; however, the extent to which these benefits persist after detraining remains unclear. This study examined the effects of detraining after treadmill running and jump exercise on trabecular bone microarchitecture and strength in growing rats. Ninety male Wistar rats were assigned to control, running, or jump groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930 each) and trained for 8\u2009weeks, followed by 0, 12, or 24\u2009weeks of detraining. Running was performed at 25\u2009m\/min for 60\u2009min\/day, and jump training consisted of 10 jumps\/day (40\u2009cm), both conducted 5\u2009days\/week. Distal femoral trabecular microarchitecture, volumetric bone mineral density (vBMD), and finite element analysis\u2013derived fracture load were assessed using micro\u2010computed tomography. Both exercise modalities increased trabecular bone volume fraction, thickness, number, vBMD, and fracture load compared with controls (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05\u20130.001). Jump exercise preferentially increased trabecular thickness, whereas running was associated with higher trabecular number. These benefits were largely maintained for up to 12\u2009weeks after exercise cessation but were no longer evident after 24\u2009weeks of detraining. These findings suggest that exercise\u2010induced improvements in trabecular bone during growth are partially lost following exercise cessation, suggesting continued mechanical loading is required to maintain these adaptations.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70941","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:57:32Z","timestamp":1779944252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of two exercise modalities and subsequent detraining on trabecular bone microarchitecture in growing male rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8653-7623","authenticated-orcid":false,"given":"Yong\u2010In","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Health and Sports Sciences Kawasaki University of Medical Welfare  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology Kawasaki University of Medical Welfare  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bonr.2019.100195","article-title":"Treadmill running and targeted tibial loading differentially improve bone mass in mice","volume":"10","author":"Berman A. G.","year":"2019","journal-title":"Bone Reports"},{"key":"e_1_2_12_3_1","first-page":"954","article-title":"The compressive behavior of bone as a two\u2010phase porous structure","volume":"59","author":"Carter D. R.","year":"1977","journal-title":"The Journal of Bone and Joint Surgery. American Volume"},{"key":"e_1_2_12_4_1","first-page":"392","article-title":"Loading protocols produce different cancellous and cortical bone responses","volume":"43","author":"Christiansen B. A.","year":"2008","journal-title":"Bone"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.7326\/0003-4819-108-6-824","article-title":"Weight bearing exercise training and lumbar bone mineral content in postmenopausal women","volume":"108","author":"Dalsky G. P.","year":"1988","journal-title":"Annals of Internal Medicine"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bone.2005.07.022","article-title":"Non\u2010invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element","volume":"37","author":"De Souza R. 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I.","year":"2003","journal-title":"Bone"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20463\/pan.2020.0001","article-title":"Differential effects of jump versus running exercise on trabecular bone architecture and strength in rats","volume":"24","author":"Ju Y. I.","year":"2020","journal-title":"Physical Activity and Nutrition"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0267466","article-title":"Effects of Korean red ginseng on three\u2010dimensional trabecular bone microarchitecture and strength in growing rats: Comparison with changes due to jump exercise","volume":"17","author":"Ju Y. 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K.","year":"1993","journal-title":"Journal of Bone and Mineral Research"},{"key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11684-020-0748-y","article-title":"Factors influencing peak bone mass gain","volume":"15","author":"Zhu X.","year":"2021","journal-title":"Frontiers in Medicine"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:55:54Z","timestamp":1779951354000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.14814\/phy2.70941"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70941","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70941"}}