{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:22Z","timestamp":1785214822392,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020270","name":"SOS Oxyg\u00e8ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obstructive sleep apnea (OSA) with an apnea\u2010hypopnea index (AHI)\u2009\u2265\u200915\/h increases the cardiovascular disease (CVD) risk in type 1 diabetes (T1D). Cardiovascular autonomic neuropathy (CAN) is a key driver of CVD in diabetes and could be increased by autonomic nervous system (ANS) dysfunction related to OSA. We compared ANS control in T1D patients with AHI\u2009\u2265\u200915\/h versus &lt;15\/h. T1D patients underwent polysomnography with heart rate variability analysis, cardiovascular reflex tests (CARTs), sudomotor function test, and urinary catecholamine analysis. Compared with patients with AHI\u2009&lt;\u200915\/h (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914), those with AHI\u2009\u2265\u200915\/h (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097) showed a lower HFnu during REM sleep (12\u2009\u00b1\u200911 vs. 25\u2009\u00b1\u200914 nu,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and a higher heart rate (73\u2009\u00b1\u20098 vs. 64\u2009\u00b1\u20099\u2009bpm;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). A significantly higher urinary norepinephrine\/epinephrine ratio was observed in patients with AHI\u2009\u2265\u200915\/h. No significant group differences were observed regarding CAN. However, AHI correlated with systolic blood pressure at orthostatism (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.54,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In T1D patients, OSA with AHI\u2009\u2265\u200915\/h showed a lower parasympathetic activity and a sympathetic activation during sleep without any significant diurnal CAN proportion increase in patients with AHI\u2009\u2265\u200915\/h. The potential impact of OSA on CAN and CVD risk in T1D patients should be assessed in further studies.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70951","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:38:37Z","timestamp":1781678317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deleterious impact of obstructive sleep apnea on autonomic nervous system control during rapid\u2010eye\u2010movement sleep in adult type 1 diabetes"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1524-8279","authenticated-orcid":false,"given":"Marion","family":"Faivre","sequence":"first","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"},{"name":"University Hospital Center of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-866X","authenticated-orcid":false,"given":"Fares","family":"Gouzi","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"},{"name":"University Hospital Center of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronia","family":"Ayoub","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Myzia","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"},{"name":"University Hospital Center of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orianne","family":"Villard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology Montpellier University Hospital  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Suc","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"},{"name":"University Hospital Center of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Hayot","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"},{"name":"University Hospital Center of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"},{"name":"Intensive Care Unit, Cardiology Department University Hospital of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[{"name":"Sleep\u2010Wake Disorders Unit, Department of Neurology Gui\u2010de\u2010Chauliac Hospital, CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-5142","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Thireau","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bughin","sequence":"additional","affiliation":[{"name":"University of Montpellier, PhyMedExp, CNRS, INSERM  Montpellier France"},{"name":"University Hospital Center of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1242"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.10.006"},{"issue":"5","key":"e_1_2_11_4_1","first-page":"665","article-title":"AASM scoring manual updates for 2017 (version 2.4)","volume":"13","author":"Berry R. 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