{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:36Z","timestamp":1783840116681,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Simulation models suggest that veno\u2010arterial extracorporeal membrane oxygenation (VA ECMO) uniformly results in left ventricular (LV) distension in cardiogenic shock (CS). This study characterized the hemodynamic response to VA ECMO in animal models of CS, and in patients with CS. LV end\u2010diastolic pressure (LVEDP) and arterial pulse pressure (PP) were assessed in 58 pigs with CS at 2 levels of VA ECMO flows. Pulmonary artery diastolic pressure (PADP), PA pulse pressure (PAPP), and arterial PP data were collected within 2\u2009h of VA ECMO from 128 patients with CS. The animal study identified 3 phenotypes. The centroids of LVEDP and arterial PP changes for Cluster 1 were +4.99 and \u22121.85\u2009mmHg, Cluster 2 +0.02 and \u22125.57\u2009mmHg, and Cluster 3 +1.31 and +15.5\u2009mmHg. The clinical study identified 3 phenotypes: \u201cpulsatile\u201d phenotype (26%, highest arterial PP), \u201clow pulsatility\u201d phenotype (52%, low arterial PP and PAPP), and \u201cLV distension\u201d phenotype (22%, elevated PADP). Acute MI was more common in the \u201cLV distension\u201d phenotype. The \u201clow pulsatility\u201d phenotype had a larger RV diameter and tricuspid regurgitation. In summary, this study identified three hemodynamic phenotypes early post\u2010VA ECMO that were related to the underlying CS etiology and RV function.<\/jats:p>","DOI":"10.14814\/phy2.70961","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:46:07Z","timestamp":1780469167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenotyping hemodynamic response to veno\u2010arterial extracorporeal membrane oxygenation in cardiogenic shock"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-1805","authenticated-orcid":false,"given":"Hoong Sern","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, College of Medicine and Health University of Birmingham  Birmingham UK"},{"name":"Department of Cardiology University Hospitals Birmingham NHS Foundation Trust  Birmingham 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