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Altered Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis and increased oxidative stress have been proposed as mechanisms underlying muscle weakness in\n                    <jats:styled-content style=\"fixed-case\">HFpEF<\/jats:styled-content>\n                    ; however, the effects of aerobic exercise on skeletal muscle physiology in this condition remain unclear. This study evaluated the impact of moderate\u2010intensity aerobic exercise on skeletal muscle contractile function, fatigue resistance, oxidative stress, and\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    expression of key Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010handling proteins in a model with features consistent with\n                    <jats:styled-content style=\"fixed-case\">HFpEF<\/jats:styled-content>\n                    . Male\n                    <jats:styled-content style=\"fixed-case\">C57BL<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">6J<\/jats:styled-content>\n                    mice were assigned to Control, Exercise,\n                    <jats:styled-content style=\"fixed-case\">HFpEF<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>\n                    + L\u2010\n                    <jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>\n                    \u2010treated), and\n                    <jats:styled-content style=\"fixed-case\">HFpEF<\/jats:styled-content>\n                    +Exercise groups.\n                    <jats:styled-content style=\"fixed-case\">HFpEF<\/jats:styled-content>\n                    \u2010like features were induced by an 8\u2010week high\u2010fat diet combined with L\u2010\n                    <jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>\n                    administration. During the final 4\u2009weeks, mice underwent aerobic exercise training. Soleus muscles were analyzed using in\u00a0vitro contractile recordings, oxidative stress markers, and\n                    <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>\n                    for\n                    <jats:styled-content style=\"fixed-case\">RyR1<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">SERCA1<\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">NCX3 mRNA<\/jats:styled-content>\n                    expression.\n                    <jats:styled-content style=\"fixed-case\">HFpEF<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>\n                    + L\u2010\n                    <jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>\n                    \u2010treated mice) showed reduced contractile force and fatigue resistance, increased oxidative stress, and decreased\n                    <jats:styled-content style=\"fixed-case\">SERCA1<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NCX3<\/jats:styled-content>\n                    expression. Aerobic exercise partially restored muscle performance and improved redox balance without normalizing Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010handling gene expression. These findings suggest that aerobic exercise enhances skeletal muscle function in\n                    <jats:styled-content style=\"fixed-case\">HFpEF<\/jats:styled-content>\n                    \u2010like models, primarily by modulating redox homeostasis.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70962","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:36:02Z","timestamp":1780637762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aerobic exercise partially improves the skeletal muscle phenotype in a model of heart failure with preserved ejection fraction in male mice"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-0090","authenticated-orcid":false,"given":"Cielo","family":"Mart\u00ednez Mart\u00ednez","sequence":"first","affiliation":[{"name":"Institute of Chemical\u2010Biological Research Michoacan University of 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