{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:36Z","timestamp":1783840116679,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prior investigations concerning finishers of the Tor des G\u00e9ants (TDG) have demonstrated oxi\u2010inflammatory response. MicroRNAs (miRNAs) have been identified as prospective biomarkers for oxi\u2010inflammatory and stress responses. This study addressed the acute responses concerning salivary miRNAs, circulating redox markers and urinary exercise\u2010induced markers during the 2019 TDG. It included seven healthy male participants who successfully completed the race. Biological specimens (blood, saliva, and urine) were collected 1\u20132\u2009days prior to the race and immediately post\u2010completion, to assess redox system and glycemia from capillary blood, creatinine and neopterin concentrations from urine, and salivary hsa\u2010miR\u2010210 and hsa\u2010miR\u201021. Circulating reactive oxygen species production increased, whereas total antioxidant capacity remained stable. Urinary creatinine and neopterin increased subsequent to the race. Nevertheless, salivary expression levels for both miR\u201021 and miR\u2010210 displayed heterogeneity among participants. Variations in miR\u2010210 were significantly correlated with changes in heart rate. The extreme mountain ultramarathon incited cumulative stress reflective of muscle damage and immune response activation. Salivary miR\u201021 and miR\u2010210 did not demonstrate acute alterations, indicating that they may not serve as highly responsive markers for the combined hypoxia\u2010strenuous exercise stressor; this finding may suggest the existence of adaptive mechanisms in finishers that facilitate their capacity to manage extreme challenges.<\/jats:p>","DOI":"10.14814\/phy2.70966","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:27:54Z","timestamp":1780558074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of extreme mountain ultramarathon on stress\u2010related biomarkers from multiple biological matrices in adult male runners"],"prefix":"10.14814","volume":"14","author":[{"given":"Cristina","family":"Purcaro","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences University \u201cG. d'Annunzio\u201d Chieti \u2013 Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Sara","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences University \u201cG. d'Annunzio\u201d Chieti \u2013 Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Vezzoli","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology \u2013 National Research Council (CNR\u2010IFC)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-3606","authenticated-orcid":false,"given":"Danilo","family":"Bondi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences University \u201cG. d'Annunzio\u201d Chieti \u2013 Pescara  Chieti 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