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This review evaluates evidence for MN loss with aging across species and anatomical motor pools. We synthesize PUBMED studies in humans, non\u2010human primates, rats and mice within the spinal cord and brainstem. Attention was given to the methodological approach used to quantify MNs and categorized based on what MNs were quantified (specific pools, vertebral levels, lateral motor columns). Methods were assessed qualitatively, based on stereological and non\u2010stereological density counting approaches, and the staining techniques identified as optimal or suboptimal by defined criteria. To facilitate cross\u2010study comparison we conducted quantitative assessments including: coefficients of variance, percentage differences between groups and standardized effect sizes calculated with Cohen's\n                    <jats:italic>d<\/jats:italic>\n                    . Across species and anatomical regions, the overall literature supports the presence of age\u2010related MN loss. Evidence is strongest in studies using robust counting approaches such as stereology, and appropriate MN markers. As age\u2010related MN degeneration is more heavily investigated and becomes a locus of intervention, future work must employ rigorous methodological standards to accurately determine the extent, regional specificity, and functional consequence of aging MN loss.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70967","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:27:17Z","timestamp":1780727237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The evidence for old age motor neuron death: A\u00a0scoping\u00a0review"],"prefix":"10.14814","volume":"14","author":[{"given":"Sang Won","family":"Cheung","sequence":"first","affiliation":[{"name":"Department of Physiology &amp; Biomedical Engineering Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-7042","authenticated-orcid":false,"given":"Matthew J.","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Department of Physiology &amp; 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