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We investigated kidney changes during the progression of DOCA\u2010salt hypertension, on renal sympathetic nerve activity (rSNA), its baroreceptor control, and markers of kidney function. Male Charles River rats were divided into independent experimental groups: controls (UNx), hypertensive (DOCA) rats treated for 3 and 5\u2009weeks. All the animals underwent nephrectomy. Mean arterial pressure (MAP) and heart rate (HR) in awake rats, and rSNA and its baroreflex in anesthetized rats. Urinary biomarkers, total protein, gamma\u2010glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH), epidermal growth factor (EGF), cystatin C, \u03b22\u2010microglobulin (\u03b22M), alpha\u20101 acid glycoprotein (AGP), neutrophil gelatinase\u2010associated lipocalin (NGAL), and albumin and renal morphology were evaluated. Baseline rSNA was elevated after 3\u2009weeks of treatment and remained increased at 5\u2009weeks, associated with an increase in MAP and reduced baroreflex sensitivity. Urinary LDH and GGT markers were higher in hypertensives, with GGT remaining elevated. AGP, NGAL, and albumin levels were unchanged. EGF, \u03b22M, and particularly cystatin C were significantly elevated in 3 and 5\u2009weeks. These findings indicate that preferential renal tubular injury associated with increased rSNA occurs during the early stage of DOCA\u2010salt hypertension.<\/jats:p>","DOI":"10.14814\/phy2.70969","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:48:10Z","timestamp":1781077690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preferential renal tubular injury and increased renal sympathetic activity occur during the early stages of\n                    <scp>DOCA<\/scp>\n                    \u2010salt hypertension in male rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0405-0027","authenticated-orcid":false,"given":"Edina","family":"Da Luz Abreu","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Physiology Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael S.","family":"Carvalhal","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Caroline","family":"Marreiros","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie F.","family":"Gerolin","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Barroso F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Renal Physiology Lab, Department of Physiology and Biophysics Institute of Biological Sciences, Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda","family":"Abreu\u2010Cunha","sequence":"additional","affiliation":[{"name":"Renal Physiology Lab, Department of Physiology and Biophysics Institute of Biological Sciences, Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9731","authenticated-orcid":false,"given":"Diogo B.","family":"Peruchetti","sequence":"additional","affiliation":[{"name":"Renal Physiology Lab, Department of Physiology and Biophysics Institute of Biological Sciences, Federal University of Minas Gerais  Belo Horizonte Minas Gerais 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