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This study examined whether pairing a\u2010tDCS with practice of a dexterous, timing\u2010based videogame task would improve performance and retention relative to SHAM stimulation. Forty healthy adults practiced a Guitar Hero\u2013style rhythm game requiring rapid finger sequencing, fine motor control, and temporal precision while receiving either 1\u2009mA a\u2010tDCS or SHAM stimulation for 20\u2009min. Performance was assessed through accuracy, best continuous note streak, and overstrums across pre\u2010test, practice, post\u2010test, and 24\u2010h retention sessions. Both groups demonstrated significant improvements across all performance measures with practice, and gains were maintained or further enhanced after 24\u2009h. However, no differences were found between the a\u2010tDCS and SHAM groups at any time point, and no time \u00d7 group interactions emerged. Overall, a\u2010tDCS did not enhance skill acquisition or retention, highlighting task specificity as a key factor in neuromodulation efficacy.<\/jats:p>","DOI":"10.14814\/phy2.70978","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:44:57Z","timestamp":1781678697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>M1<\/scp>\n                    a\u2010\n                    <scp>tDCS<\/scp>\n                    does not acutely enhance motor skill acquisition of a dexterous, timing\u2010based videogame task in adults"],"prefix":"10.14814","volume":"14","author":[{"given":"Brandon O.","family":"Blake","sequence":"first","affiliation":[{"name":"School of Health and Human Sciences Indiana University\u2013Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter P.","family":"Burton","sequence":"additional","affiliation":[{"name":"School of Health and Human Sciences Indiana University\u2013Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia E.","family":"Duchow","sequence":"additional","affiliation":[{"name":"School of Health and Human Sciences Indiana University\u2013Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn","family":"McCallion","sequence":"additional","affiliation":[{"name":"School of Health and Human Sciences Indiana University\u2013Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brach","family":"Poston","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition Sciences University of Nevada\u2010Las Vegas  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-1398","authenticated-orcid":false,"given":"Zachary A.","family":"Riley","sequence":"additional","affiliation":[{"name":"School of Health and Human Sciences Indiana University\u2013Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.01981"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2025.2111436"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.085"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.06.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.01.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3661"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1399\u201013.2013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.2.1117"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.10.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2025.01.058"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2025.149884"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.12.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.04.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1972\u201024.2025"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/603502"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2000.4004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.6.3321"},{"key":"e_1_2_9_19_1","first-page":"3","article-title":"The ten\u2010twenty electrode system of the international federation. 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