{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T07:41:44Z","timestamp":1794382904246,"version":"4.9.0"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Renal dysfunction in heart failure (HF) involves congestion\u2010associated injury, tubular damage, and inflammatory remodeling. Although SGLT2 inhibitors improve renal outcomes in HF, associated renal structural changes in nondiabetic HF remain incompletely characterized. Kidney samples from a previously published cohort of nondiabetic male Wistar rats with myocardial infarction\u2013induced HF treated with empagliflozin (10\u2009mg\/kg\/day) or vehicle for 4\u2009weeks were analyzed histologically and by immunohistochemistry. Congestion\u2010associated histological changes, tubular atrophy, tubular morphometric changes, CD68\n                    <jats:sup>+<\/jats:sup>\n                    macrophages, CD206\n                    <jats:sup>+<\/jats:sup>\n                    macrophages, and CD3\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes were evaluated. HF animals exhibited increased congestion\u2010associated histological scores and tubular atrophy compared with sham controls. Empagliflozin was associated with lower congestion\u2010associated scores in HF animals (median 1 [1] vs. 3.5 [3, 4],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0401) and reduced tubular atrophy (median 1 [0\u20131] vs. 3 [1\u20133.75],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0150). Empagliflozin did not reduce total CD68\n                    <jats:sup>+<\/jats:sup>\n                    macrophage counts in HF animals, but was associated with increased CD206\n                    <jats:sup>+<\/jats:sup>\n                    macrophage representation (9.0\u2009\u00b1\u20091.9 vs. 5.5\u2009\u00b1\u20091.6 cells\/field,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0058), reduced CD3\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell infiltration (12.0\u2009\u00b1\u20093.5 vs. 21.0\u2009\u00b1\u20098.0 cells\/field,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0051), and increased tubular large\u2010lumen profiles. Empagliflozin was associated with attenuation of congestion\u2010associated histological changes, reduced tubular atrophy, tubular morphometric remodeling, and altered renal immune cell composition in nondiabetic HF.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70980","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:14:37Z","timestamp":1781583277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Empagliflozin and renal histological changes in an experimental model of heart failure in male rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3715-4030","authenticated-orcid":false,"given":"Aline Cavalcanti Toledo","family":"Wisnivesky","sequence":"first","affiliation":[{"name":"Faculdade de Medicina da USP Unidade de Medicina Interdisciplinar em Cardiologia, Instituto do Cora\u00e7\u00e3o (InCor)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Guilherme Ferreira","family":"Bertacchi","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Anatomia Patol\u00f3gica, Hospital das Cl\u00ednicas Faculdade de Medicina da USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6718-8456","authenticated-orcid":false,"given":"Bruno","family":"Caramelli","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da USP Unidade de Medicina Interdisciplinar em Cardiologia, Instituto do Cora\u00e7\u00e3o (InCor)  S\u00e3o Paulo 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