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In this study, stress induced modulation of these axes was examined using 20 pigs\/treatment either weaned (WN), weaned with feed\/water restriction 9\u2009h (FR), transported 9\u2009h (TRANS), or remaining with sow (SOS) and euthanized at 32 or 56\u2009h post\u2010weaning. Serum cortisol, thyroxine (T4), and triiodothyronine (T3) were measured before weaning and after 24, 32, and 56\u2009h with no difference in cortisol concentrations among treatments at any timepoint. However, both T3 and T4 decreased post\u2010weaning in FR, TRANS, and WN compared to SOS. Expression of 23 genes of interest was evaluated across the hypothalamus, pituitary, thyroid, and adrenal glands of TRANS and SOS pigs at 56\u2009h to understand the underlying mechanism.\n                    <jats:italic>TSHB<\/jats:italic>\n                    ,\n                    <jats:italic>DIO3<\/jats:italic>\n                    , and\n                    <jats:italic>POMC<\/jats:italic>\n                    expression was decreased in the pituitary while\n                    <jats:italic>DIO3<\/jats:italic>\n                    in the thyroid was increased, with upregulation in\n                    <jats:italic>MC2R<\/jats:italic>\n                    also observed. Collectively, these results suggest acute stressors in swine can induce type I allostasis within the HPT axis and modulate sensitivity within the HPA.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70984","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:11:09Z","timestamp":1782461469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Weaning stress induced alterations to the hypothalamic\u2010pituitary\u2010thyroid and \u2010adrenal axes in swine"],"prefix":"10.14814","volume":"14","author":[{"given":"Isabel B.","family":"Walpole","sequence":"first","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette Indiana USA"},{"name":"Department of Animal and Food Sciences University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylyn G.","family":"Rudy","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayeon","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette Indiana USA"},{"name":"Department of Animal and Food Sciences University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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