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Sixty\u2010four male and female 42\u2010day\u2010old Sprague\u2013Dawley rats were assigned to control, TA (50\u2009mg\/kg), SAC (10% ethanol +20% fructose), or SAC+TA groups and treated for 10\u2009weeks using a voluntary gelatine\u2010based model. Growth parameters, feed intake, visceral fat, fasting glucose, insulin, HOMA\u2010IR, lipid profiles, and hepatic outcomes, including mass, TBARS, gene expression, and histological features, were assessed. SAC reduced feed intake without affecting body mass. Females exposed to SAC showed increased visceral fat, elevated hepatic TBARS, reduced hepatocyte density, and more pronounced steatosis, indicating oxidative and structural susceptibility. In contrast, males exhibited increased HDL\u2010cholesterol with reduced hepatic TBARS, suggesting sex\u2010specific differences in hepatic metabolic adaptation. TA co\u2010treatment prevented the SAC\u2010associated increase in hepatic TBARS but did not preserve hepatocyte density or alter steatosis in females. Glucose homeostasis, insulin resistance, triglycerides, and hepatic expression of\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    ,\n                    <jats:italic>SREBP\u20101<\/jats:italic>\n                    ,\n                    <jats:italic>IL\u201010<\/jats:italic>\n                    ,\n                    <jats:italic>NF\u2010\u03baB1<\/jats:italic>\n                    , and\n                    <jats:italic>TNF\u2010\u03b1<\/jats:italic>\n                    were unaffected across groups. Overall, SAC induces sex\u2010dependent hepatic alterations during adolescence, with females showing heightened vulnerability. TA did not produce a measurable additional benefit when combined with SAC under the conditions used.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70992","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:40:16Z","timestamp":1782805216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010specific hepatic effects of sweetened alcohol consumption and tannic acid intervention in adolescent rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9818-7673","authenticated-orcid":false,"given":"Toluwase E.","family":"Olanipekun","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Biomedical Sciences, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladiran 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