{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:40:35Z","timestamp":1785577235723,"version":"3.56.0"},"reference-count":54,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tuft cells act as sentinels that amplify type 2 inflammation primarily by activating type 2 innate lymphoid cells (ILC2s). Although normally absent from the distal lung, ectopic tuft cells form after severe lung injury including influenza infection in mice. Here, we investigated the function of these ectopic tuft cells in shaping innate immunity following influenza injury. We observed that IFN\u03b3 deficiency was associated with an increase in tuft cell and ILC2 expansion, whereas ILC2 deficiency was associated with reduced tuft cell expansion, consistent with a reciprocal regulatory axis. Tuft cell\u2013deficient mice exhibited expansion of ILC1s and ILC3s after influenza injury resolution. Single\u2010cell RNA\u2010seq of influenza infected whole lung revealed transcriptional signatures consistent with type 1 pathway activation and oxidative stress in the tuft cell\u2010deficient mice. Following influenza injury and subsequent\n                    <jats:italic>Alternaria alternata<\/jats:italic>\n                    challenge, tuft cell\u2013deficient mice also showed neutrophilic and ILC3 expansion. Together, these data are consistent with the presence of a distal\u2010airway tuft\u2010cell\u2013ILC2 circuit that may help shape inflammatory responses to viral injury and aeroallergens.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71000","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:29:16Z","timestamp":1783830556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influenza\u2010induced tuft cell expansion is associated with changes in\n                    <scp>ILC2<\/scp>\n                    populations in the distal lungs of mice"],"prefix":"10.14814","volume":"14","author":[{"given":"Maria Elena","family":"Gentile","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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