{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:07:33Z","timestamp":1784092053184,"version":"3.55.0"},"reference-count":74,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This scoping review describes cardiopulmonary fitness in non\u2010operated patients with pectus excavatum and maps the reporting of hemoglobin and arterial oxygen content during exercise. Four databases (PubMed, ScienceDirect, CINAHL, and SPORTDiscus) were searched from inception to February 15th, 2025. Cross\u2010sectional studies, cohort studies, and randomized controlled trials reporting exercise capacity or exercise testing outcomes were included. Among 612 identified records, 31 studies involving 2937 patients met all eligibility criteria. Seventeen studies reported maximal oxygen uptake (VO\n                    <jats:sub>2<\/jats:sub>\n                    max) as a percentage of predicted values, ranging from 62%\u2009\u00b1\u200925% to 101.0%\u2009\u00b1\u200918.3%, indicating substantial heterogeneity in exercise capacity. Hemoglobin concentration was quantified in only one study (11.6 to 17.3\u2009g\/100\u2009mL). Pulse oximetry was assessed in 15 studies but quantitatively reported in four (95.5%\u2009\u00b1\u20092.1% to 97.4%\u2009\u00b1\u20091.2%). Blood gases were assessed in five studies, with results reported in two, including alveolar\u2013arterial oxygen pressure difference at maximal exercise and arterial oxygen pressure decline during effort. Overall, exercise capacity seems to be impaired in patients with PEx, and hemoglobin and oxygen\u2010related parameters remain underreported.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71005","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:51:48Z","timestamp":1783399908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise impairment in patients with pectus excavatum? A scoping review of evidence and role of arterial content change during effort"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9646-8091","authenticated-orcid":false,"given":"Maxime","family":"Lokietek","sequence":"first","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MITOVASC, Equipe CarMe, SFR ICAT, F\u201049000  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lecoq","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MITOVASC, Equipe CarMe, SFR ICAT, F\u201049000  Angers France"},{"name":"Sports Medicine Department Angers University Hospital  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Filaire","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery University Hospital of Saint Etienne, North Hospital  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Noury\u2010Desvaux","sequence":"additional","affiliation":[{"name":"Institute of Physical Education and Sport Training Catholic University of the West  Les Ponts\u2010de\u2010C\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00e8ve","family":"Houle","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MITOVASC, Equipe CarMe, SFR ICAT, F\u201049000  Angers France"},{"name":"Sports Medicine Department Angers University Hospital  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Abraham","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MITOVASC, Equipe CarMe, SFR ICAT, F\u201049000  Angers France"},{"name":"Sports Medicine Department Angers University Hospital  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.09.037"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.020"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.121558"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2025.10.036"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-018-1406-0"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2024.07.005"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-025-06195-4"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-23-00268"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-24-00523"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1962.tb04235.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50118"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80268-7"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.1999.0714"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-020-04738-5"},{"issue":"3","key":"e_1_2_13_17_1","first-page":"564","article-title":"Symptomatic pectus deformities of the chest","volume":"126","author":"Castile R. G.","year":"1982","journal-title":"American Review of Respiratory Disease"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181bd0fc4"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmr.2010.06.015"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050703"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/apc.APC_121_18"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015412"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezae166"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2023.01.002"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2025.162177"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00137.2004"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80530-5"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jspd.2018.11.002"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12050655"},{"issue":"1","key":"e_1_2_13_30_1","first-page":"125","article-title":"Cardiorespiratory function is significantly improved following corrective surgery for severe pectus excavatum. Proposed treatment guidelines","volume":"41","author":"Haller J. A.","year":"2000","journal-title":"The Journal of Cardiovascular Surgery"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25540"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.721"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-23-957"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022149"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.06.019"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2016.09.09"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.3.663"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-025-06200-w"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-5-69"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-025-06229-x"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12512"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.03.034"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.3.870"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-08038-7"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.17712\/1658-3183.1527"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-08"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(94)70414-7"},{"issue":"2","key":"e_1_2_13_48_1","first-page":"e77","article-title":"Cardiopulmonary response following surgical repair of pectus excavatum in adult patients","volume":"40","author":"Neviere R.","year":"2011","journal-title":"European journal of cardio\u2010thoracic surgery : official journal of the European Association for Cardio\u2010thoracic Surgery"},{"key":"e_1_2_13_49_1","unstructured":"NHS England. (2019).Clinical commissioning policy: Surgery for pectus deformity (all ages) (NHS England Reference: 170113P)."},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198202000-00001"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.024"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2021.103790"},{"issue":"4","key":"e_1_2_13_53_1","first-page":"613","article-title":"Comparison of a ramp cycle ergometer and a staged AssaultBike protocol for the assessment of VO2max","volume":"16","author":"Pearson R. C.","year":"2023","journal-title":"International Journal of Exercise Science"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)80128-4"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.08.060"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2024.2349827"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2021-000940"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1861-y"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14222488"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2013.tb00500.x"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e328336a124"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.12.013"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr170"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1087"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivw007"},{"key":"e_1_2_13_67_1","volume-title":"Cardiopulmonary fitness","author":"Umapathi K. K.","year":"2023"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.14490"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201611-852FR"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0003-5"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0292835"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)35630-2"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.07.051"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)70096-5"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-4526-9"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.71005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:42:45Z","timestamp":1784090565000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.71005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":74,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.14814\/phy2.71005"],"URL":"https:\/\/doi.org\/10.14814\/phy2.71005","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71005"}}