{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:07:35Z","timestamp":1784092055565,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sympathetic and parasympathetic nervous system (SNS, PNS) control of cardiac rhythm during muscle metaboreflex activation (MMA) are important components of the physiological response to exercise but poorly understood. Therefore, SNS and PNS control of cardiac rhythm at the onset of MMA following exercise was examined in healthy young and old adults. Fourteen young (26\u2009\u00b1\u20092\u2009years) and 10 old (62\u2009\u00b1\u20093\u2009years) healthy adults performed 90\u2010s, one\u2010legged, isometric, calf exercise at 70% maximal voluntary contraction (MVC) and underwent a 0% MVC control trial, with unilateral circulatory occlusion beginning 5\u2009s before exercise cessation and maintained for 30\u2009s following exercise to isolate MMA. Absolute and normalized low\u2010frequency (aLF, nLF) and high\u2010frequency (aHF, nHF) bands and LF\/HF were analyzed during a 30\u2009s baseline period and the first 30\u2009s of MMA following exercise (70% MVC) or continued rest (0% MVC). A time\u2010trial interaction in LF\/HF was observed in young adults (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.043), with LF\/HF elevated during 0\u201310\u2009s of MMA compared to 10\u201330\u2009s during the 70% MVC trial. This interaction was not observed in old adults (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.490). These results indicate that healthy young adults exhibit restoration of PNS control of cardiac rhythm at the onset of MMA following exercise, whereas this restoration is absent in healthy old adults.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71009","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:53:08Z","timestamp":1783399988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autonomic control of cardiac rhythm at the onset of muscle metaboreflex activation following exercise in healthy young and old adults"],"prefix":"10.14814","volume":"14","author":[{"given":"Tyler E.","family":"Oliver","sequence":"first","affiliation":[{"name":"Department of Exercise and Health Sciences University of Massachusetts Boston  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel E.","family":"S\u00e1nchez\u2010Hechavarr\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Facultad de Medicina Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n  Concepci\u00f3n Chile"},{"name":"Facultad de Ciencias de la Salud Universidad Adventista de Chile  Chill\u00e1n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Carrazana\u2010Escalona","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Facultad de Medicina Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n  Concepci\u00f3n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A.","family":"Blaha","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence I.","family":"Sinoway","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-1946","authenticated-orcid":false,"given":"Rachel C.","family":"Drew","sequence":"additional","affiliation":[{"name":"Department of Exercise and Health Sciences University of Massachusetts Boston  Boston Massachusetts USA"},{"name":"Penn State Heart and Vascular Institute Penn State College of Medicine  Hershey Pennsylvania 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