{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:50:45Z","timestamp":1786549845604,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High\u2010altitude environments impose unique physiological challenges due to reduced barometric pressure and lower inspired oxygen partial pressure, raising concerns about the safety of face mask use in individuals with chronic obstructive pulmonary disease. While evidence at sea level shows that surgical and N95 masks modestly impair gas exchange\u2014slightly reducing oxygen uptake, oxygen saturation\u2014they consistently increase perceived exertion, dyspnea, and fatigue. Limited studies conducted under hypobaric conditions\u2014typically involving small sample sizes, brief mask\u2010wearing periods, and healthy participants. However, data at higher altitudes and in patients with COPD remain scarce. Emerging epidemiological evidence suggests that COPD prevalence may decrease with increasing altitude, yet high\u2010altitude residence can alter pathophysiology and could increase vulnerability to hypoxemia and hypercapnia during mask use in advanced disease. Existing studies in COPD at sea level report generally modest physiological effects with short\u2010term mask use, but their small sample sizes and short exposure durations limit generalizability. This perspective highlights the urgent need for well\u2010designed studies evaluating both acute and chronic physiological responses to prolonged mask use in COPD patients at high altitudes to inform evidence\u2010based public health recommendations.<\/jats:p>","DOI":"10.14814\/phy2.71010","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:24:58Z","timestamp":1784874298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Friend or foe: Face masks in patients with\n                    <scp>COPD<\/scp>\n                    at high altitude"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-6882","authenticated-orcid":false,"given":"Javier Josue","family":"Flores\u2010Mamani","sequence":"first","affiliation":[{"name":"Instituto Acad\u00e9mico Cient\u00edfico Quispe\u2010Cornejo  La Paz Bolivia"},{"name":"Medical School Universidad Mayor de San Andr\u00e9s  La Paz Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-3880","authenticated-orcid":false,"given":"Andree","family":"Ingala\u2010Tapia","sequence":"additional","affiliation":[{"name":"Instituto Acad\u00e9mico Cient\u00edfico Quispe\u2010Cornejo  La Paz Bolivia"},{"name":"Medical School Universidad Mayor de San Andr\u00e9s  La Paz Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-0179","authenticated-orcid":false,"given":"Armin Alvaro","family":"Quispe\u2010Cornejo","sequence":"additional","affiliation":[{"name":"Instituto Acad\u00e9mico Cient\u00edfico Quispe\u2010Cornejo  La Paz Bolivia"},{"name":"Department of Intensive Care Erasme University Hospital, Universit\u00e9 Libre de Bruxelles  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2009.09.006"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252649199"},{"key":"e_1_2_13_4_1","volume-title":"Yellow Book","author":"CDC","year":"2025"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1027521"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00806\u20102024"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010020\u201001704\u2010y"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801581"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.581763"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010020\u201001748\u20100"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010017\u20100643\u20105"},{"key":"e_1_2_13_12_1","doi-asserted-by":"crossref","unstructured":"Imray C. 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