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However, much remains to be learned about how this process is regulated in cancerous cells. Here we investigated the role of two co\u2010transcribed microRNA (miRNA) species, miR\u201015a\/16, in regulating cellular protein translation, cell growth, metabolic processes, and clinical features in PDAC. Using cultured PDAC models, we show that overexpression of miR\u201015a\/16 in cancerous cells slows proliferation and attenuates protein synthesis rates. Bioinformatics analysis reveals that these miRNAs target a broad suite of pathophysiological and metabolic pathways, including numerous genes in cancer\u2010 and protein\u2010related processes. Finally, using publicly available patient data, we report that miR\u201015a\/16 expression is lower in PDAC tumors and in patients with pancreatitis than in healthy controls, and that high expression of miR\u201015a\/16 in tumors is associated with improved survival in patients. Our results indicate that miR\u201015a\/16 act as regulators of protein metabolism in PDAC, with potential clinical implications for the management of this devastating disease.<\/jats:p>","DOI":"10.14814\/phy2.71015","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:30:27Z","timestamp":1784269827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MicroRNA<\/scp>\n                    \u201015a\/16 regulate protein metabolism and are associated with clinical outcomes in pancreatic ductal adenocarcinoma"],"prefix":"10.14814","volume":"14","author":[{"given":"Patrick J.","family":"Ryan","sequence":"first","affiliation":[{"name":"Muscle Biology Laboratory, Department of Kinesiology and Sports Management Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany 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