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This study compared 50% O\n                    <jats:sub>2<\/jats:sub>\n                    (INT50) and 75% O\n                    <jats:sub>2<\/jats:sub>\n                    (INT75) in well\u2010trained male mice, which had increased maximal work values by 7.7\u2010fold through a 7\u2010week voluntary running program, during a 4\u2010week treadmill program. Results showed that INT75, but not INT50, significantly improved endurance capacity compared to the normoxic\u2010trained (ET) group (Bayes factor, BF \u22653). The enhanced exercise capacity in the INT75 group was linked to higher levels of metabolic enzymes (citrate synthase, 3\u2010hydroxyacyl\u2010CoA\u2010dehydrogenase, carnitine palmitoyl transferase\u20102, and phosphofructokinase) in the diaphragm and increased pyruvate dehydrogenase complex activity in the red gastrocnemius (Gr) and plantaris (PL) muscles (BF \u22653). Glutathione peroxidase\u20101 protein levels in the PL muscle were significantly lower in INT75 (vs ET, 0.76\u2010fold, BF \u22653). Additionally, INT75 mice exhibited increased PGC1\u03b1 levels in the left ventricle, despite decreased cytochrome\u2010c oxidase activity. In contrast, the INT50 group showed a shift toward fast\u2010twitch muscle fibers in the Gr. In conclusion, the ergogenic effects of intermittent hyperoxia depend on oxygen concentration. INT at 75% O\n                    <jats:sub>2<\/jats:sub>\n                    significantly enhances endurance capacity in well\u2010trained mice by optimizing metabolic enzyme activity across skeletal and respiratory muscles.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71020","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:02:29Z","timestamp":1784365349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of different oxygen concentrations during intermittent hyperoxic training on endurance capacity in well\u2010trained male mice"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-2071","authenticated-orcid":false,"given":"Junichi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Laboratory of Exercise Physiology, Health and Sports Sciences, Course of Sports Education, Department of Education Hokkaido 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.053181"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00964.2005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1969.tb00674.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00719.2018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7905"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00922.2012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.141.1.87"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2009.0335"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891\u20105849(00)00161\u20101"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.36.21021"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6522.746"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2013.05.027"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/25.2.269"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.3.R951"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.07.002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4AY00804A"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010023\u201001063\u20104"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165417"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14194"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103481"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0170304"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.4.1072"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.140.3573.1329"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00169.2004"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90220-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00628.2020"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000169610.33318.54"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.266.2.R375"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030514"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010082"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14609"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(17)31580\u20106"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470110546.ch6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003677\u2010200204000\u201000009"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(69)13005-0"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44337\u2010025\u201000248\u20102"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14182"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14780"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15534"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.16117"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70341"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12576\u2010022\u201000839\u2010z"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.250956"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453620"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13423\u2010020\u201001798\u20105"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.04.011"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1517-z"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318234eb6f"}],"container-title":["Physiological 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