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While oxidative stress links stress to cardiometabolic risk, its relationship with neuroendocrine markers and hemodynamics remains unclear. Within these profiles, we investigated resting oxidative stress parameters and their associations with neuroendocrine markers and hemodynamic reactivity. We included 362 participants (aged 20\u201365\u2009years) and recorded beat\u2010to\u2010beat hemodynamic reactivity during the Stroop\u2010Color\u2010Word\u2010Conflict test. We categorized \u03b1\u2010responders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200947), \u03b2\u2010responders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200968) and mixed\u2010\u03b1\/\u03b2\u2010responders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009247) based on cardiac output (\u2206%CO) and Windkessel arterial compliance (\u2206%Cwk) reactivity. Baseline fasting urine and blood samples were analyzed for neuroendocrine markers and oxidative stress parameters. Predominant \u03b1\u2010responders were older with higher hypertension prevalence than other responders. Oxidative stress parameters were comparable between \u03b1\u2010 and \u03b2\u2010responders. In \u03b1\u2010responders, SOD and GR inversely associated with \u2206%CO and GPx positively with \u2206%Cwk (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.026). In \u03b2\u2010responders, u\u2010NE\/Cr positively associated with GGT, ACTH inversely with ROS and tGSH positively with \u2206%CO (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.014). Our findings highlight divergence in cardiometabolic risk pathways. In \u03b1\u2010responders, enzymatic antioxidants may support downstream vascular hemodynamic buffering in response to high\u2010pressure\u2010related vascular risk. In \u03b2\u2010responders, sympathetic\u2010driven increases in glutathione turnover could reflect antioxidant adaptation to preserve cardiac function during acute stress.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71024","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:09:54Z","timestamp":1784635794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential associations of oxidative stress parameters with neuroendocrine markers and hemodynamic reactivity in acute mental stress\u2010induced adrenergic reactivity profiles: The\n                    <scp>SABPA<\/scp>\n                    study"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-0953","authenticated-orcid":false,"given":"Dewald","family":"Naud\u00e9","sequence":"first","affiliation":[{"name":"Hypertension in Africa Research Team North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-7331","authenticated-orcid":false,"given":"Wayne","family":"Smith","sequence":"additional","affiliation":[{"name":"Hypertension in Africa Research Team North\u2010West University  Potchefstroom South Africa"},{"name":"South African Medical Research Council Unit for Hypertension and Cardiovascular Disease North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-3341","authenticated-orcid":false,"given":"Catharina MC","family":"Mels","sequence":"additional","affiliation":[{"name":"Hypertension in Africa Research Team North\u2010West University  Potchefstroom South Africa"},{"name":"South African Medical Research Council Unit for Hypertension and Cardiovascular Disease North\u2010West University  Potchefstroom South 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