{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:28:49Z","timestamp":1786685329662,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We investigated the effects of a high\u2010fat diet (HFD) and treadmill running on bone marrow fat (BMF) and bone properties in mice. Four\u2010week\u2010old male mice (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096\/group) were assigned to four groups: standard diet (STD) or HFD (60% kcal from fat), under sedentary or exercise conditions. Mice performed treadmill running (6\u201318\u2009m\/min, 30\u2009min\/day, 5\u2009days\/week) for 16\u2009weeks. At 20\u2009weeks, body weight, adipose tissue mass, bone mineral density (BMD), bone strength, histomorphometry, and bone turnover markers were assessed. HFD significantly increased body weight and adipose tissue mass, whereas exercise attenuated HFD\u2010induced weight gain. Absolute BMD was unaffected by diet but lower in exercised mice. Weight\u2010adjusted BMD was lower in HFD\u2010fed mice and higher in exercised mice. BMF was elevated by HFD and was not reduced by exercise. The resorption marker was increased by HFD and was not attenuated by exercise, whereas the formation marker was elevated only in exercised mice. The ratio of bone resorption to bone formation markers was higher in HFD\u2010fed mice. No significant diet \u00d7 exercise interactions were observed for turnover markers. In conclusion, HFD during growth increases BMF, whereas treadmill running attenuates HFD\u2010induced weight gain but does not prevent increases in BMF.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71033","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:20:59Z","timestamp":1785388859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of high\u2010fat diet and treadmill running on bone marrow fat and bone properties in young male mice"],"prefix":"10.14814","volume":"14","author":[{"given":"Yuri","family":"Takamine","sequence":"first","affiliation":[{"name":"Graduate School of Health and Sports Science Juntendo University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-3312","authenticated-orcid":false,"given":"Noriko","family":"Ichinoseki\u2010Sekine","sequence":"additional","affiliation":[{"name":"Graduate School of Health and Sports Science Juntendo University  Chiba Japan"},{"name":"Faculty of Liberal Arts The Open University of Japan  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0241-1183","authenticated-orcid":false,"given":"Takamasa","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Meijo University  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8465-5439","authenticated-orcid":false,"given":"Toshinori","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Graduate School of Health and Sports Science Juntendo University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1076-2757","authenticated-orcid":false,"given":"Shuichi","family":"Machida","sequence":"additional","affiliation":[{"name":"Graduate School of Health and Sports Science Juntendo University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0522-9512","authenticated-orcid":false,"given":"Hisashi","family":"Naito","sequence":"additional","affiliation":[{"name":"Graduate School of Health and Sports Science Juntendo University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2336"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"372","article-title":"Obesity, osteoporosis and bone metabolism","volume":"20","author":"Gkastaris 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