{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:28:50Z","timestamp":1786685330164,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The hepatosplanchnic vascular response to isolated abdominal organ injury remains poorly defined. The aim of this review was to synthesize the available evidence on macrovascular hepatosplanchnic flow and organ\u2010specific microvascular perfusion following isolated abdominal injury or surgery. PubMed\/MEDLINE was searched through 11 May 2026 for human and animal studies reporting visceral hemodynamic changes after abdominal trauma, experimental injury, or surgery. Systematic\u2010review methods included structured study selection, data extraction, and design\u2010specific risk\u2010of\u2010bias assessment within a PRISMA\u2010based scoping\u2010review framework. Owing to heterogeneity, findings were synthesized narratively. Twenty\u2010six studies were included: 14 human and 12 animal studies. Nineteen investigated pneumoperitoneum or elevated intra\u2010abdominal pressure, four major abdominal surgery, and three other models. Perfusion reductions became more frequent with increasing pressure and were significantly more common at &gt;15 than &lt;10\u2009mmHg (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031). Higher pressures also impaired compensatory mechanisms, including the hepatic arterial buffer response. After major surgery, portal and total hepatosplanchnic flow generally increased early postoperatively, while gastric mucosal perfusion deteriorated, indicating macro\u2013microcirculatory dissociation. Only one study directly examined primary intra\u2010abdominal injury and assessed microcirculation alone. Evidence remains indirect, heterogeneous, and methodologically limited. Studies combining serial macrovascular and organ\u2010specific microvascular measurements are required to define the hepatosplanchnic response.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71051","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:30:31Z","timestamp":1786606231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatosplanchnic perfusion changes following isolated abdominal trauma and surgery: A scoping review of evidence dominated by pneumoperitoneum models"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8438-2680","authenticated-orcid":false,"given":"Vid","family":"Pivec","sequence":"first","affiliation":[{"name":"Clinical Department for Abdominal and General Surgery University Clinical Centre Maribor  Maribor Slovenia"},{"name":"Gravitational Physiology and Medicine Research Unit, Division of Physiology and Pathophysiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation Medical University of Graz  Graz Austria"},{"name":"Department for General and Visceral Surgery LKH S\u00fcdweststeiermark  Wagna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Bergauer","sequence":"additional","affiliation":[{"name":"Gravitational Physiology and Medicine Research Unit, Division of Physiology and Pathophysiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation Medical University of Graz  Graz Austria"},{"name":"Department for General and Visceral Surgery LKH S\u00fcdweststeiermark  Wagna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hawliczek","sequence":"additional","affiliation":[{"name":"Gravitational Physiology and Medicine Research Unit, Division of Physiology and Pathophysiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-0723","authenticated-orcid":false,"given":"Nandu","family":"Goswami","sequence":"additional","affiliation":[{"name":"Gravitational Physiology and Medicine Research Unit, Division of Physiology and Pathophysiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation Medical University of Graz  Graz Austria"},{"name":"Center for Space and Aviation Health, College of Medicine Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health  Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000153034.54128.5e"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"105","article-title":"The assessment of hepatic portal flow using Doppler's technique in patients after 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