{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:28:53Z","timestamp":1786685333103,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    CD31\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells possess angiogenic properties and have been termed angiogenic T\u2010cells (T\n                    <jats:sub>ANG<\/jats:sub>\n                    ) and are altered in number with advancing age. We examined circulating T\n                    <jats:sub>ANG<\/jats:sub>\n                    subsets and VEGF\u2010A content in young (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916, 18\u201330\u2009years) and older (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916, 50\u201365\u2009years) males by flow cytometry. Cardiorespiratory fitness ( O\n                    <jats:sub>2<\/jats:sub>\n                    max) was quantified. Circulating IL\u20106 and cytomegalovirus (CMV) serostatus were determined by immunoassays. T\n                    <jats:sub>ANG<\/jats:sub>\n                    contained more VEGF\u2010A than CD31\n                    <jats:sup>\u2212<\/jats:sup>\n                    T\u2010cells (CD31\n                    <jats:sup>+<\/jats:sup>\n                    : 9374\u2009\u00b1\u20098587\u2009AU vs. CD31\n                    <jats:sup>\u2212<\/jats:sup>\n                    : 8722\u2009\u00b1\u20098149\u2009AU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), also evident in CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    subsets. Older adults possessed fewer CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>ANG<\/jats:sub>\n                    cells as a proportion of total CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells than younger adults (young: 35%\u2009\u00b1\u200911%; older: 24%\u2009\u00b1\u20099%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004), and all T\n                    <jats:sub>ANG<\/jats:sub>\n                    subsets from older adults exhibited higher VEGF\u2010A content than younger adults (CD3\n                    <jats:sup>+<\/jats:sup>\n                    : young: 6081\u2009\u00b1\u20094001\u2009AU; older: 13426\u2009\u00b1\u200910,945\u2009AU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019; CD31\n                    <jats:sup>+<\/jats:sup>\n                    : young: 6373\u2009\u00b1\u20093972\u2009AU; older: 15660\u2009\u00b1\u200912,829\u2009AU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011; CD8\n                    <jats:sup>+<\/jats:sup>\n                    : young: 6335\u2009\u00b1\u20094029\u2009AU; older: 11216\u2009\u00b1\u20098056\u2009AU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.043). T\n                    <jats:sub>ANG<\/jats:sub>\n                    cells and VEGF\u2010A expression were not independently associated with CMV serostatus, IL\u20106 or  O\n                    <jats:sub>2<\/jats:sub>\n                    max. Advancing age is associated with a pathological T\n                    <jats:sub>ANG<\/jats:sub>\n                    phenotype which may contribute to age\u2010related inflammation.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71057","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:55:27Z","timestamp":1786341327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CD31<\/scp>\n                    <sup>+<\/sup>\n                    T\u2010cells express greater\n                    <scp>VEGF<\/scp>\n                    \u2010A than\n                    <scp>CD31<\/scp>\n                    <sup>\u2212<\/sup>\n                    counterparts with expression exacerbated with advancing age in male adults"],"prefix":"10.14814","volume":"14","author":[{"given":"Luke","family":"Stephen","sequence":"first","affiliation":[{"name":"School of Energy, Geoscience, Infrastructure and Society, Institute of Life and Earth Sciences Heriot\u2010Watt University  Edinburgh UK"},{"name":"School of Applied Sciences Edinburgh Napier University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3257-7619","authenticated-orcid":false,"given":"Graham","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Applied Sciences Edinburgh Napier University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Muggeridge","sequence":"additional","affiliation":[{"name":"School of Applied Sciences Edinburgh Napier University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-3607","authenticated-orcid":false,"given":"Melanie","family":"Leggate","sequence":"additional","affiliation":[{"name":"School of Applied Sciences Edinburgh Napier University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignesh","family":"Chandrakumar","sequence":"additional","affiliation":[{"name":"School of Applied Sciences Edinburgh Napier University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-3915","authenticated-orcid":false,"given":"Mark","family":"Ross","sequence":"additional","affiliation":[{"name":"School of Energy, Geoscience, Infrastructure and Society, Institute of Life and Earth Sciences Heriot\u2010Watt University  Edinburgh UK"},{"name":"School of Applied Sciences Edinburgh Napier University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30344"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RI0716-335R"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00531-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00522.2013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00768"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12750"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204686"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.06.014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2024.1389789"},{"key":"e_1_2_10_12_1","first-page":"4140","article-title":"Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis","volume":"55","author":"Freeman M. 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