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We aimed to verify this phenomenon in rats and to investigate whether electroacupuncture (EA) pretreatment at bilateral Feishu (BL13) and Zusanli (ST36) acupoints (once daily for 3\u2009days) exerts protective effects. In an MI\/R\u2010induced lung injury model in SD rats, EA pretreatment significantly improved lung function and reduced pathological damage (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01, respectively). It also attenuated the pulmonary inflammatory response and decreased the expression of high mobility group box\u00a01 (HMGB1) and receptor for advanced glycation end products (RAGE) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 or\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Intratracheal administration of recombinant HMGB1 (rHMGB1) to upregulate lung HMGB1\/RAGE signaling impaired the pulmonary protective effect of EA (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Together, these findings demonstrate that EA pretreatment mitigates MI\/R\u2010induced lung injury by inhibiting HMGB1\/RAGE signaling.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71066","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:41:33Z","timestamp":1790394093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture pretreatment alleviates myocardial ischemia\/reperfusion\u2010induced lung injury by inhibiting the expression of\n                    <scp>HMGB1<\/scp>\n                    \/\n                    <scp>RAGE<\/scp>\n                    in male rats"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8510-2981","authenticated-orcid":false,"given":"Chenlong","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shuguang Hospital, Shanghai University of Traditional 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-8463","authenticated-orcid":false,"given":"Jiangang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shuguang Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai 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