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In this study, we assessed the effects of 72\u2010h of hand immobilization on motor functions in healthy adults. Twenty\u2010eight participants were randomized to an immobilization or control group and completed a motor test battery before and after the intervention. The battery assessed maximal and explosive strength, quantified as maximal voluntary contraction (MVC) force and rate of force development (RFD), fatigability during sustained maximal contractions, force steadiness during submaximal contractions, and manual dexterity. Immobilization induced domain\u2010specific impairments in motor performance. MVC force and RFD declined significantly following immobilization, indicating susceptibility of maximal and explosive strength to short\u2010term disuse. In contrast, no significant changes were observed in the selected parameters of fatigability during sustained maximal contractions, including the fatigue time constant and plateau force. Force steadiness showed a selective increase in relative force variability, whereas absolute force variability remained unchanged. Manual dexterity was not reduced from baseline, but immobilization attenuated the test\u2013retest performance improvements observed in the control group and contralateral non\u2010immobilized hand. These findings demonstrate that hand immobilization induces task\u2010 and domain\u2010specific alterations in motor performance rather than a uniform decline, preferentially affecting motor domains that require high force production.<\/jats:p>","DOI":"10.14814\/phy2.71068","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:34:44Z","timestamp":1787290484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of short\u2010term hand immobilization on motor functions across domains in adults"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5712-3795","authenticated-orcid":false,"given":"Lasse","family":"Jespersen","sequence":"first","affiliation":[{"name":"Movement &amp; Neuroscience, Department of Nutrition, Exercise and Sports (NEXS) University of Copenhagen  Copenhagen 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