{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:19:05Z","timestamp":1787811545158,"version":"build-2784847793"},"reference-count":65,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102024\u201003782"],"award-info":[{"award-number":["RGPIN\u20102024\u201003782"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Eccentric contractions performed to long muscle lengths impose high mechanical stress and strain on the muscle fiber, providing a stimulus for longitudinal growth (i.e., increases in serial sarcomeres number (SSN)). Conventional (CONV) resistance training incorporates eccentric and concentric phases; however, mechanical loading is constrained by the concentric phase. Eccentric overload (ECC\n                    <jats:sub>OVERLOAD<\/jats:sub>\n                    ) training has a maximal load throughout the eccentric phase increasing the potential for greater sarcomerogenesis. The purpose was to investigate ECC\n                    <jats:sub>OVERLOAD<\/jats:sub>\n                    and CONV training on mechanical and morphological adaptation in ovary\u2010intact and OVX rats. Intact and OVX Sprague\u2013Dawley rats performed 4\u2009weeks (\u00d73\/week) of ECC\n                    <jats:sub>OVERLOAD<\/jats:sub>\n                    or CONV resistance training. Mechanical measures were tested pre\u2010 and post\u2010training. Fascicle length and sarcomere length were measured to obtain SSN. Torque increased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) similarly across groups at the shorter muscle (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.075) and greater at the longer muscle lengths (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) in OVX rats. In the soleus, there was a training\u00d7 hormone status\u00d7 training group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028) interaction, such that intact rats showed the greatest improvement in SSN with ECC\n                    <jats:sub>OVERLOAD<\/jats:sub>\n                    (~13%), which was higher than both CONV intact (~3%) and OVX rats in either training condition (ECC\n                    <jats:sub>OVERLOAD<\/jats:sub>\n                    ~1%, CONV ~5%). Therefore, OVX had a blunted adaptation in longitudinal muscle remodeling in response to ECC\n                    <jats:sub>OVERLOAD<\/jats:sub>\n                    training.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71070","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:09:12Z","timestamp":1787555352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serial sarcomere adaptation to eccentric overload training is blunted in ovariectomized rats"],"prefix":"10.14814","volume":"14","author":[{"given":"Amelia","family":"Rilling","sequence":"first","affiliation":[{"name":"Department of Human Health and Nutritional Sciences College of Biological Sciences, University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Q.","family":"Kirkup","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences College of Biological Sciences, University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-1006","authenticated-orcid":false,"given":"Avery","family":"Hinks","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences College of Biological Sciences, University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3165-4536","authenticated-orcid":false,"given":"Martino V.","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-0740","authenticated-orcid":false,"given":"Geoffrey A.","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences College of Biological Sciences, University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107793.2001.t01\u20101\u201000613.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2021.1921854"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2024.100996"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.05.006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2010.1081"},{"issue":"6","key":"e_1_2_12_7_1","first-page":"748","article-title":"Current concepts of muscle and tendon adaptation to strength and conditioning","volume":"10","author":"Brumitt J.","year":"2015","journal-title":"International Journal of Sports Physical Therapy"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00481.2005"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00481.2005"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039472\u2010z"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.218776"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010009\u20100778\u20101"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.06.025"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.03.033"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.11.050"},{"issue":"5","key":"e_1_2_12_16_1","first-page":"589","article-title":"The respective roles of muscle length and muscle tension in sarcomere number adaptation of Guinea\u2010pig soleus muscle","volume":"75","author":"Tour E. H.","year":"1979","journal-title":"Journal of Physiology\u2010Paris"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00128.2007"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.115.1.375"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010017\u20100395\u2010y"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237771"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1949.0019"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00205.2023"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.059491"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00041.2024"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70036"},{"key":"e_1_2_12_26_1","volume-title":"StatPearls","author":"Hsu D.","year":"2025"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14\u2010266668"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00428.2012"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071658"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.724649"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25227"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107580.2006.00549.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000531"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk4030061"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00439.2015"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2010.0316"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010016\u20100526\u20109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.98"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-54498-6.00011-4"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.035071"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01583.2005"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01305.2006"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01029.2005"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.08.005"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0840095"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2025.101089"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107793.2001.00333.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.1353"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00713.2025"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.829274"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.07.017"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013\u20102835"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768\u2010198810001\u201000013"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107793.2001.0571a.x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003677\u2010200301000\u201000008"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00609.2018"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010012\u20109500\u20100"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980\u20105918.033.ao12"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010017\u20100755\u20106"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.10.001"},{"issue":"3","key":"e_1_2_12_61_1","first-page":"459","article-title":"Changes in sarcomere length and physiological properties in immobilized muscle","volume":"127","author":"Williams P. E.","year":"1978","journal-title":"Journal of Anatomy"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.249816"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106587"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17495"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1590\/1809\u20102950\/14720923012016"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109290(95)80009\u20103"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.71070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:42:38Z","timestamp":1787809358000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.71070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":65,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.14814\/phy2.71070"],"URL":"https:\/\/doi.org\/10.14814\/phy2.71070","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71070"}}