{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:19:00Z","timestamp":1787811540130,"version":"build-2784847793"},"reference-count":60,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Partial bladder outlet obstruction (pBOO) is a fibroproliferative disorder that results in poorly compliant, high\u2010pressure bladders due to lower urinary tract occlusion. The mechanisms governing pBOO\u2010induced bladder remodeling remain poorly understood. The goals of the present study were to profile global and region\u2010specific transcriptomes of porcine bladders in response to pBOO using RNA sequencing and to identify genes and pathways differentially affected in the bladder dome and trigone by obstructive injury. Nine adult female Yucatan mini\u2010swine were randomized and divided into either nonsurgical controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095) or those subjected to pBOO for 4\u2009weeks (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094). Post\u2010pBOO swine demonstrated bladder smooth muscle hypertrophy as well as significant declines in bladder capacity (35%\u2009\u00b1\u20097% of baseline) and compliance (38%\u2009\u00b1\u200910% of baseline). The global transcriptome of obstructed bladders revealed enrichment of processes related to loss of urothelial barrier function, immune activation, cell cycle regulation, extracellular matrix organization, and signal transduction similar to human and rodent evaluations of pBOO. Moreover, our data also showed that adaptive responses to pBOO are regionally dependent rather than globally uniform, with zonal\u2010specific divergence observed across hypoxic, fibrotic, metabolic, and neuronal pathways between the obstructed dome and trigone. These results highlight the regional heterogeneity of bladder responses to obstructive urologic disease.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71074","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:20:07Z","timestamp":1787206807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of global and region\u2010specific transcriptomic alterations in the bladder following acute partial bladder outlet obstruction in female mini\u2010swine"],"prefix":"10.14814","volume":"14","author":[{"given":"Yi Xi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caila","family":"Ruiz\u2010May","sequence":"additional","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Tarik","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Rourke","sequence":"additional","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhina","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Gelman","sequence":"additional","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-3664","authenticated-orcid":false,"given":"Joshua R.","family":"Mauney","sequence":"additional","affiliation":[{"name":"Department of Urology University of California, Irvine  Orange California USA"},{"name":"Department of Biomedical Engineering University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2018.0113"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.080834"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-024-01417-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.2267"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2003"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"120","article-title":"Comparison of the role of anticholinergics and alpha\u20101 adrenergic blockers in bladder Management in Posterior Urethral Valves: A pilot randomized control trial","volume":"109","author":"Bade R.","year":"2025","journal-title":"Urologia Internationalis"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.06.17"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2005.09.004"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25353"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1992.tb15791.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191215"},{"issue":"6","key":"e_1_2_12_13_1","first-page":"S3","article-title":"Bladder outlet obstruction: Etiology and evaluation","volume":"7","author":"Dmochowski R. 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