{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:43:16Z","timestamp":1789468996161,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009886","name":"American Academy of Sleep Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009886","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute cannabis use and its primary psychoactive constituent tetrahydrocannabinol (THC) can induce postural dizziness, indicating increased risk of orthostatic instability. However, it is unknown if vulnerabilities persist the morning after bedtime THC consumption. This study investigated the influence of bedtime THC consumption on cardiovascular variables during an orthostatic challenge. Nine individuals with no cannabis use and eight individuals who regularly use cannabis participated in a tilt table test associated with a 3\u2010day in\u2010laboratory stay. Participants underwent an acclimatization day, followed by a placebo dosing day, and a 10\u2009mg THC dosing day. Placebo and THC pills were given 1\u2009h before a participant's habitual bedtime, and the tilt table test was performed ~1\u2009h upon awakening. Participants were instrumented with an electrocardiogram and an automated sphygmomanometer. Fluid intake and output were measured throughout the study. The morning after THC administration, individuals with no cannabis use reported a higher frequency of dizziness and exhibited a significant reduction in both diastolic blood pressure and heart rate reactivity to tilt (reactivity\u2009=\u2009tilt \u2010 baseline) compared to the morning after placebo. Our results indicate a potential increased risk for orthostatic instability the morning after cannabis consumption in individuals with no cannabis use history.<\/jats:p>","DOI":"10.14814\/phy2.71076","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:30:26Z","timestamp":1787981426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bedtime tetrahydrocannabinol ingestion reduces morning orthostatic cardiovascular reactivity in adults: An exploratory study"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-7852","authenticated-orcid":false,"given":"Joshua E.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"College of Nursing and Health Sciences Texas A&amp;M University\u2010Corpus Christi  Corpus Christi Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia V.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaTroy D.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noal A.","family":"Clemons","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar H.","family":"Ordaz","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Emens","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"VA Portland Healthcare System  Portland Oregon USA"},{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh S.","family":"Thosar","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Knight Cardiovascular Institute, School of Medicine Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"School of Nursing Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Oregon Health and Science University\u2010Portland State University School of Public Health  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Shea","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-7082","authenticated-orcid":false,"given":"Nicole P.","family":"Bowles","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; 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