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This study seeks to determine the therapeutic potential of interleukin (IL)\u201010 administered following acute sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ) exposure in mice. C57BL\/6 male and female mice were exposed to SO\n                    <jats:sub>2<\/jats:sub>\n                    gas at 125\u2009ppm for 4\u2009h and subsequently treated 2\u20133\u2009h later with IL\u201010 (1\u2009\u03bcg) or vehicle control by intratracheal instillation for a total of 3 doses over 2\u2009days with comparisons to sham\u2010treated mice (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200920 mice\/group). IL\u201010 treatment reduced SO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced weight loss with corresponding reductions in SO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced circulating markers of inflammation (pentraxin\u20102 and fibrinogen). IL\u201010 reduced SO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced markers of lung cell permeability (surfactant protein\u2010D and protein), and cell death (lactate dehydrogenase [LDH]). SO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced lung infiltrates of neutrophils and activated macrophages were reduced with IL\u201010 treatment. IL\u201010 reduced SO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced increases in total protein, Substance P, apoptotic cells, post\u2010translational citrullinated and malondialdehyde\u2010acetaldehyde\u2010modified proteins, and vimentin. Compared to female mice, SO\n                    <jats:sub>2<\/jats:sub>\n                    exposure led to greater increases in serum pentraxin\u20102, fibrinogen, LDH levels, and lavage fluid cells in males. In conclusion, short\u2010term, intratracheal IL\u201010 therapy administered after acute SO\n                    <jats:sub>2<\/jats:sub>\n                    exposure favorably modulates acute lung injury consequences to suggest a therapeutic potential to decrease adverse systemic and lung effects.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71079","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:52:26Z","timestamp":1787719946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intratracheal interleukin\u201010 administration reduces acute lung injury induced by sulfur dioxide exposure in mice"],"prefix":"10.14814","volume":"14","author":[{"given":"Amy J.","family":"Nelson","sequence":"first","affiliation":[{"name":"Division of Allergy &amp; Immunology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care &amp; Sleep University of Nebraska Medical Center  Omaha Nebraska USA"},{"name":"Veterans Affairs Nebraska\u2010Western Iowa Health Care System, Research Service  Omaha Nebraska USA"},{"name":"Department of Environmental, Agricultural and Occupational Health, College of Public Health University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley W.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Department of Veterans Affairs Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Diaz","sequence":"additional","affiliation":[{"name":"Division of Allergy &amp; Immunology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Gleason","sequence":"additional","affiliation":[{"name":"Division of Allergy &amp; Immunology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Duryee","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2010Western Iowa Health Care System, Research Service  Omaha Nebraska USA"},{"name":"Division of Rheumatology &amp; Immunology, Department of Internal Medicine, College of Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2010Western Iowa Health Care System, Research Service  Omaha Nebraska USA"},{"name":"Division of Rheumatology &amp; Immunology, Department of Internal Medicine, College of Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2010Western Iowa Health Care System, Research Service  Omaha Nebraska USA"},{"name":"Division of Rheumatology &amp; Immunology, Department of Internal Medicine, College of Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-2563","authenticated-orcid":false,"given":"Jill A.","family":"Poole","sequence":"additional","affiliation":[{"name":"Division of Allergy &amp; Immunology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00120.2023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00018.2015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.621"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1161067"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312948"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40900"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00239.2023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02094-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.10.008"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1547691X.2022.2148782"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01653"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2022-0237"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2018.11.003"},{"issue":"6","key":"e_1_2_11_16_1","first-page":"32","article-title":"Deployment\u2010related lung disorders","volume":"32","author":"Krefft S. 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