{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:43:16Z","timestamp":1789468996158,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS117638"],"award-info":[{"award-number":["NS117638"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["#2IK6RD002734\u201006"],"award-info":[{"award-number":["#2IK6RD002734\u201006"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Orthostatic intolerance is common in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) and may worsen daily functioning. Although hypovolemia has been proposed as a contributor, its relationship to objective orthostatic abnormalities remains uncertain. We examined whether measured blood\u2010volume abnormalities were associated with standardized lean\u2010test outcomes. Adults meeting the 1994 ME\/CFS criteria and reporting substantial post\u2010exertional malaise underwent a 10\u2010min lean test with capnography, followed 8 days later by total blood volume (TBV) measurement using the Daxor BVA\u2010100. Supine hypocapnia was defined as baseline end\u2010tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    (eTCO\n                    <jats:sub>2<\/jats:sub>\n                    ) &lt;34\u2009mmHg; postural orthostatic syndrome of hypocapnia (POSH) as normal supine eTCO\n                    <jats:sub>2<\/jats:sub>\n                    with any leaning value &lt;34\u2009mmHg; and postural orthostatic tachycardia syndrome (POTS) as a heart\u2010rate increase \u226530 beats\/min or absolute heart rate \u2265120 beats\/min. Among 49 participants, TBV was hypovolemic in 35%, normovolemic in 43%, and hypervolemic in 22%; red blood cell volume was deficient in 49%. Overall, 55.1% had at least one lean\u2010test abnormality, most commonly POSH (40.8%). Abnormalities did not differ by TBV or red blood cell volume category. Static blood\u2010volume categories were not associated with lean\u2010test\u2010defined orthostatic abnormalities in ME\/CFS, suggesting contributions from autonomic, vascular, respiratory, or cerebrovascular mechanisms.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71087","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:15:11Z","timestamp":1789020911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total blood volume and red blood cell volume are not associated with orthostatic intolerance in adults with myalgic encephalomyelitis\/chronic fatigue syndrome"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-8898","authenticated-orcid":false,"given":"Tadahiro","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-1785","authenticated-orcid":false,"given":"Donna M.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Cardiology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Blate","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Norweg","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane B.","family":"Cook","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin USA"},{"name":"Department of Kinesiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.","family":"Natelson","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2007.08.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530120053041"},{"key":"e_1_2_11_4_1","first-page":"985","article-title":"Cardiovascular deconditioning during space flight and the use of saline as a countermeasure to orthostatic intolerance","volume":"56","author":"Bungo M. W.","year":"1985","journal-title":"Aviation, Space, and Environmental Medicine"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun324"},{"key":"e_1_2_11_6_1","volume-title":"Beyond Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Redefining an Illness","author":"Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome","year":"2015"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.4.605"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084716"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn123"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090055"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.06.013"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2281.1999.00154.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.517"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2014.01.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.106.035972"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14309"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-015-9650-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20227"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200606000-00001"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2000.9201"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5918-6-2"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03289-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2015-000381"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110241"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000160356.97313.5D"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.1.52"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01826195"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0900277"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40790-6"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051369"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00352"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02819-0"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2020.01.003"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.71087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:20:53Z","timestamp":1789464053000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.71087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.14814\/phy2.71087"],"URL":"https:\/\/doi.org\/10.14814\/phy2.71087","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71087"}}