{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:43:18Z","timestamp":1789468998263,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This double\u2010blind, randomized, crossover study investigated whether acute cacao polyphenol (CP) ingestion attenuates neuromuscular fatigue in 19 healthy young male adults. After consuming CP or placebo, participants performed sustained isometric ankle dorsiflexion at 25% of maximal voluntary isometric contraction (MVIC) torque until task failure. Neuromuscular function (MVIC torque, voluntary activation [VA%], doublet torque) and electromyographic activity were assessed before, immediately after, and during recovery (1 and 5\u2009min). Salivary chromogranin A and \u03b1\u2010amylase were measured at baseline and 1\u2009min post\u2010task. Only VA% and chromogranin A showed significant condition \u00d7 time interactions (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027\u20130.039). VA% significantly decreased from before to immediately after the task and 1\u2009min post\u2010task in both conditions (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.002), with significantly higher values in the CP condition than in placebo immediately after and 1\u2009min post\u2010task (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.037). Chromogranin A significantly increased from baseline to 1\u2009min post\u2010task in the placebo condition (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) but not in the CP condition (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.083). These findings suggest that acute CP ingestion attenuates the decline in central motor drive and autonomic stress responses following strenuous exercise, without altering performance or peripheral recovery, supporting its potential as a nutritional strategy for modulating central fatigue.\n                  <\/jats:p>","DOI":"10.14814\/phy2.71095","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:28:46Z","timestamp":1788841726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute pre\u2010exercise oral intake of cacao polyphenols attenuates central fatigue development during sustained low\u2010intensity ankle dorsiflexion exercise in healthy young male adults"],"prefix":"10.14814","volume":"14","author":[{"given":"Ikumi","family":"Morikawa","sequence":"first","affiliation":[{"name":"Graduate School of Engineering and Science Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashiyu","family":"Ono","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering and Science Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Osada","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering and Science Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-0484","authenticated-orcid":false,"given":"Yasuyuki","family":"Fujii","sequence":"additional","affiliation":[{"name":"SIT Research Laboratories Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5819-1150","authenticated-orcid":false,"given":"Midori","family":"Natsume","sequence":"additional","affiliation":[{"name":"Meiji Co., Ltd.  Hachioji\u2010shi Tokyo Japan"},{"name":"Meiji Holdings Co., Ltd.  Hachioji\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-7053","authenticated-orcid":false,"given":"Naomi","family":"Osakabe","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering and Science Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"},{"name":"Bioscience Course, Bioscience and Engineering Program, College of Systems Engineering and Science Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-6830","authenticated-orcid":false,"given":"Ryota","family":"Akagi","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering and Science Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"},{"name":"Sports Engineering Course, Bioscience and Engineering Program, College of Systems Engineering and Science Shibaura Institute of Technology  Saitama\u2010shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00280.2020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01041.2018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.638007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216932120"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP092060"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00022.2012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00775.2016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10030517"},{"key":"e_1_2_11_10_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010022\u201002874\u20103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00162.2014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2025.101195"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.1.158"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.4.1725"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201076160\u20109"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858408314986"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2016.1252428"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010023\u201006720\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00093"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256\u2010200636100\u201000006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000166946.94871.9b"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.07.028"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167462"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101681.2008.05021.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010010\u20101480\u20100"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9010061"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22\u201015\u201006321.2002"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091\u20103057(02)00818\u20103"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0963\u20109969(00)00069\u20107"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010025\u201005872\u20105"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.71095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.71095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:21:11Z","timestamp":1789464071000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.71095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.14814\/phy2.71095"],"URL":"https:\/\/doi.org\/10.14814\/phy2.71095","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71095"}}